{"id":"W2145162000","doi":"10.1161/circulationaha.113.005300","title":"Activation of Histone Deacetylase-6 Induces Contractile Dysfunction Through Derailment of α-Tubulin Proteostasis in Experimental and Human Atrial Fibrillation","year":2013,"lang":"en","type":"article","venue":"Circulation","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":168,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research","keywords":"HDAC6; Proteostasis; Acetylation; Medicine; Histone deacetylase; Histone deacetylase inhibitor; Contractility; Cell biology; Microtubule; HDAC4; Internal medicine; Cancer research; Pharmacology; Histone; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002081002,0.00027092,0.0002617797,0.0001623007,0.0001469243,0.0001586828,0.0001277887,0.0002508386,0.001921424],"category_scores_gemma":[0.0001550696,0.0001013746,0.000286392,0.0001439678,0.0002693261,0.00008709609,0.0001155392,0.0004692285,0.0003036509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001823913,"about_ca_system_score_gemma":0.0001017755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002400887,"about_ca_topic_score_gemma":0.0003138749,"domain_scores_codex":[0.9998934,0.00002601278,0.00001404821,0.00002362661,0.00001632327,0.00002654038],"domain_scores_gemma":[0.9999366,0.000009556517,0.00002057378,0.000009054851,0.000005890924,0.0000183962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002159151,0.0002139619,0.002086841,0.0001276217,0.00003973804,0.0003337856,0.00003278211,0.00004878753,0.9906635,0.00008358714,0.0001706388,0.004039675],"study_design_scores_gemma":[0.0006458941,0.006878846,0.08961195,0.00002912107,0.0001631283,0.004581851,0.0001090373,0.001222091,0.8898711,0.0001471114,0.006728209,0.00001169115],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923279,0.005031638,0.001137398,0.0001315334,0.0000806769,0.00003954855,0.0002534505,0.00004697569,0.0009510301],"genre_scores_gemma":[0.9968953,0.001519048,0.0003648122,0.00005787441,0.00002492326,0.00003734309,0.0004420524,0.000005623744,0.0006528629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001921424,"threshold_uncertainty_score":0.006427765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02295494013413874,"score_gpt":0.3241158601854788,"score_spread":0.30116092005134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}