{"id":"W2145165064","doi":"10.1128/jvi.00362-11","title":"The Ribonucleotide Reductase R1 Subunits of Herpes Simplex Virus 1 and 2 Protect Cells against Poly(I · C)-Induced Apoptosis","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique; Centre Hospitalier de l’Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Cycloheximide; Herpes simplex virus; Ribonucleotide reductase; Molecular biology; Apoptosis; Interferon; Viral protein; Transfection; HeLa; TRIF; Cell biology; Virology; Cell culture; Receptor; Virus; Innate immune system; Biochemistry; Protein biosynthesis; Cell; Protein subunit; Toll-like receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000178406,0.0004667028,0.0003141485,0.0001690556,0.0001083846,0.0003138123,0.0001740346,0.0002349733,0.0006899228],"category_scores_gemma":[0.0001717395,0.0001311723,0.0002484361,0.00009755303,0.000134316,0.0001749966,0.0001474059,0.000435135,0.0003660664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000207968,"about_ca_system_score_gemma":0.0001972521,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000260206,"about_ca_topic_score_gemma":0.0003308752,"domain_scores_codex":[0.9998651,0.00002555428,0.00001427596,0.00002501312,0.0000400101,0.00003003548],"domain_scores_gemma":[0.9998506,0.0000248321,0.00005499458,0.00002725214,0.00002087976,0.00002145894],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001438187,0.00001549766,0.0001378627,0.0000394712,0.000009084993,0.00002191791,0.00001012488,0.00005013568,0.9978758,0.00005107428,0.00003013348,0.001615156],"study_design_scores_gemma":[0.0000209572,0.0005012099,0.003273391,0.000007197279,0.00002251434,0.00022565,0.00001866725,0.0003901908,0.9933815,0.00003798265,0.002114982,0.000005704168],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880775,0.007714225,0.002564834,0.000101902,0.00005173253,0.00003365119,0.0002261956,0.0001035779,0.001126438],"genre_scores_gemma":[0.9915098,0.002925705,0.002548178,0.00008151207,0.00002385481,0.00003710092,0.000754286,0.00002334193,0.002096227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006899228,"threshold_uncertainty_score":0.002308011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03605279485968741,"score_gpt":0.2701354066973577,"score_spread":0.2340826118376703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}