{"id":"W2145174883","doi":"10.1128/aac.44.3.590-597.2000","title":"A Dose Ranging Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of Lamivudine in Children and Adolescents with Chronic Hepatitis B","year":2000,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"Wellcome Trust","keywords":"Lamivudine; Pharmacokinetics; Medicine; Hepatitis B virus; Nucleoside analogue; Hepatitis B; Oral administration; Gastroenterology; Dose-ranging study; Chronic hepatitis; Internal medicine; Area under the curve; Pharmacology; Nucleoside; Immunology; Virus; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005618904,0.0005195504,0.0009648256,0.0001794544,0.000259571,0.0003195282,0.0002232092,0.0004129561,0.000761222],"category_scores_gemma":[0.001943874,0.0002827907,0.0004081929,0.0002739744,0.0004720576,0.0002063569,0.0001359235,0.0008269669,0.0001985371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003834111,"about_ca_system_score_gemma":0.0003947048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008750282,"about_ca_topic_score_gemma":0.0009702524,"domain_scores_codex":[0.9995621,0.0002061078,0.00003126707,0.00005204148,0.00008353635,0.00006504118],"domain_scores_gemma":[0.9987074,0.0005033587,0.0003086549,0.00006782784,0.00009808823,0.000314532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1961112,0.01990453,0.4280916,0.0008118154,0.001011901,0.001805763,0.00188269,0.003192374,0.1379611,0.0003065827,0.001981927,0.2069385],"study_design_scores_gemma":[0.01925501,0.4423675,0.5054104,0.00005531447,0.000529981,0.003315286,0.0004056884,0.001373634,0.01637333,0.000129742,0.01073072,0.00005342572],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987086,0.0007746081,0.0001060776,0.00003203812,0.000007806228,0.00005597098,0.00007206618,0.000007751302,0.0002350707],"genre_scores_gemma":[0.9981286,0.0006092913,0.0004737236,0.0001087837,0.00002982117,0.000112125,0.0003060025,0.000005133078,0.0002266031],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009648256,"threshold_uncertainty_score":0.00297159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006293282436625288,"score_gpt":0.2446713212641394,"score_spread":0.2383780388275142,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}