{"id":"W2145184104","doi":"10.1002/ardp.201200267","title":"Novel Dithiocarbamic Acid Esters Derived from 6‐Aminomethyl‐4‐anilinoquinazolines and 6‐Aminomethyl‐4‐anilino‐3‐cyanoquinolines as Potent EGFR Inhibitors","year":2012,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Chemistry; Lapatinib; Kinase; ErbB; Stereochemistry; Positive control; Cell culture; MTT assay; Biochemistry; Combinatorial chemistry; In vitro; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003215023,0.0008291211,0.0007559368,0.0002512261,0.0004603063,0.0001545285,0.0007114633,0.0002758783,0.0005202213],"category_scores_gemma":[0.0001900672,0.000795279,0.0003316945,0.0003136483,0.0004863814,0.0005621304,0.0005524832,0.0006727161,0.000323074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001215682,"about_ca_system_score_gemma":0.0001187759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003353184,"about_ca_topic_score_gemma":0.00002437038,"domain_scores_codex":[0.9959667,0.00008166011,0.0009907681,0.00106749,0.0006053294,0.001288015],"domain_scores_gemma":[0.997013,0.0006272807,0.0004013407,0.001015617,0.000116607,0.0008261714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001055522,0.0007621169,0.01614559,0.0001214869,0.0002946657,0.000008343428,0.001588905,0.00001263042,0.9517073,0.0003868089,0.0002535348,0.02861306],"study_design_scores_gemma":[0.001920349,0.00003763743,0.04481072,0.0001147812,0.0004502314,0.0001100025,0.0008943366,0.000482493,0.9419625,0.0009163881,0.007173322,0.001127207],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867306,0.004940892,0.001267896,0.0009600738,0.0005048425,0.0003483067,0.0004368766,0.0003415702,0.004468933],"genre_scores_gemma":[0.9895621,0.0007423284,0.005577807,0.0006702268,0.002284859,0.0002257162,0.0003497263,0.0001642746,0.0004229551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02866513,"threshold_uncertainty_score":0.9994498,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258803895058756,"score_gpt":0.2654141216796416,"score_spread":0.242826082729054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}