{"id":"W2145184104","doi":"10.1002/ardp.201200267","title":"Novel Dithiocarbamic Acid Esters Derived from 6‐Aminomethyl‐4‐anilinoquinazolines and 6‐Aminomethyl‐4‐anilino‐3‐cyanoquinolines as Potent EGFR Inhibitors","year":2012,"lang":"en","type":"article","venue":"Archiv der Pharmazie","topic":"Quinazolinone synthesis and applications","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Emergent BioSolutions (Canada)","funders":"","keywords":"Chemistry; Lapatinib; Kinase; ErbB; Stereochemistry; Positive control; Cell culture; MTT assay; Biochemistry; Combinatorial chemistry; In vitro; Receptor; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001484964,0.0005129172,0.0003118591,0.0003189815,0.0001054145,0.0001793384,0.0004026631,0.0003657561,0.001270237],"category_scores_gemma":[0.0001040871,0.0001756936,0.0002067268,0.0001904771,0.0001463548,0.0002167932,0.0001581053,0.000357329,0.0003014438],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002183186,"about_ca_system_score_gemma":0.0002030588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003030502,"about_ca_topic_score_gemma":0.00104399,"domain_scores_codex":[0.999934,0.00001441924,0.000005532171,0.00001025197,0.00001674782,0.0000191216],"domain_scores_gemma":[0.9999458,0.000007099902,0.00001476647,0.000003825006,0.00001025281,0.00001823573],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002989405,0.00007999317,0.0001437746,0.0003249588,0.00001867467,0.0002238803,0.00002311797,0.0005132755,0.9862009,0.0005143991,0.0001807711,0.01147728],"study_design_scores_gemma":[0.0002644728,0.001968235,0.00133288,0.00001699081,0.00005369125,0.0004964517,0.00001644475,0.001126485,0.9823542,0.0001006667,0.01224485,0.00002471905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9263139,0.03666408,0.02281492,0.0003545359,0.0002589025,0.0005913512,0.0007839475,0.0003860139,0.01183227],"genre_scores_gemma":[0.9697734,0.01110131,0.01408338,0.000134307,0.00004559241,0.0002200373,0.0005186287,0.00001715265,0.004106263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001270237,"threshold_uncertainty_score":0.004249334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02258803895058756,"score_gpt":0.2654141216796416,"score_spread":0.242826082729054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}