{"id":"W2145231631","doi":"10.1158/0008-5472.can-10-1316","title":"Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"NKG2D; Downregulation and upregulation; MHC class I; Major histocompatibility complex; Biology; Cytotoxicity; Receptor; Cytotoxic T cell; Cell; Natural killer cell; Interleukin 12; Immunology; Cell biology; Cancer research; Immune system; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008244871,0.0001885089,0.0002741926,0.00009128789,0.00008662148,0.0002821925,0.00007925072,0.0001382546,0.001481916],"category_scores_gemma":[0.0001317782,0.00008759124,0.0001195198,0.00008514742,0.0001786302,0.000148826,0.0001476053,0.0003471368,0.0002328719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072571,"about_ca_system_score_gemma":0.0001072511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001839457,"about_ca_topic_score_gemma":0.0002734642,"domain_scores_codex":[0.999876,0.00003215409,0.00001163366,0.00002036113,0.00003041531,0.00002941932],"domain_scores_gemma":[0.9998726,0.00002587652,0.00004573141,0.00002415674,0.00001228726,0.00001927961],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001704384,0.00002965308,0.0006495779,0.00004069653,0.000008048641,0.00006039504,0.00002297614,0.00007608555,0.996987,0.00006217867,0.00005833303,0.001834536],"study_design_scores_gemma":[0.00002629381,0.001416091,0.0245902,0.00001198304,0.00002685524,0.000704442,0.00006491044,0.0008857027,0.9687008,0.00007312332,0.003493209,0.000006218801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953134,0.002511049,0.001017148,0.00006510079,0.00001968467,0.00002549301,0.0001126629,0.00007435516,0.0008610445],"genre_scores_gemma":[0.9988012,0.0004473401,0.0002517025,0.00002312142,0.000004154997,0.00001184041,0.00008886791,0.00000516259,0.0003665802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001481916,"threshold_uncertainty_score":0.004957497,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03544514701153032,"score_gpt":0.3274022213792387,"score_spread":0.2919570743677084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}