{"id":"W2145231631","doi":"10.1158/0008-5472.can-10-1316","title":"Chemotherapy-Induced Genotoxic Stress Promotes Sensitivity to Natural Killer Cell Cytotoxicity by Enabling Missing-Self Recognition","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"NKG2D; Downregulation and upregulation; MHC class I; Major histocompatibility complex; Biology; Cytotoxicity; Receptor; Cytotoxic T cell; Cell; Natural killer cell; Interleukin 12; Immunology; Cell biology; Cancer research; Immune system; In vitro; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0009050312,0.0001896841,0.0002080558,0.0002311835,0.0005364363,0.00008720586,0.0001660234,0.00032451,0.002872247],"category_scores_gemma":[0.0001905535,0.0001754945,0.00007739593,0.0003284891,0.00009975379,0.0001942458,0.00008282511,0.001798642,0.00100511],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001915847,"about_ca_system_score_gemma":0.0001534134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008020601,"about_ca_topic_score_gemma":0.0001813777,"domain_scores_codex":[0.9980611,0.0004657481,0.0002270351,0.0004872279,0.0001259784,0.0006329618],"domain_scores_gemma":[0.998908,0.0002253702,0.00007132635,0.0003175252,0.0004089611,0.00006882819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003303992,0.0002257646,0.00009189371,0.00003127166,0.00004771776,0.000002567842,0.0008371646,3.972143e-7,0.9646832,0.000001727468,0.0202935,0.01345442],"study_design_scores_gemma":[0.0007208,0.0001576776,0.0004721929,0.00004630626,0.000006996849,0.0000151504,0.0002168812,0.00001948694,0.9529958,0.00001206668,0.04512913,0.0002074481],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927437,0.0004056109,0.0000492779,0.001154923,0.004031851,0.0006564337,0.00001983596,0.000122606,0.0008158066],"genre_scores_gemma":[0.9884484,0.00008764001,0.00006087299,0.0003859593,0.0001876226,0.0001090458,0.0001536183,0.0000364022,0.01053048],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02483563,"threshold_uncertainty_score":0.9997727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03544514701153032,"score_gpt":0.3274022213792387,"score_spread":0.2919570743677084,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}