{"id":"W2145263179","doi":"10.1158/1078-0432.ccr-05-2452","title":"Germ Line Mutations of Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer Patients with Small Bowel Cancer: International Society for Gastrointestinal Hereditary Tumours Collaborative Study","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital","funders":"","keywords":"MSH6; MLH1; PMS2; MSH2; DNA mismatch repair; Medicine; Colorectal cancer; Population; Cancer; Germline mutation; Lynch syndrome; Mutation; Internal medicine; Cancer research; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00142319,0.0003448445,0.0008014617,0.0002362478,0.000203027,0.00003574861,0.0004093604,0.0001822222,0.0002799644],"category_scores_gemma":[0.0005561317,0.0002934473,0.0003604859,0.001095793,0.001056023,0.0001055856,0.0002002036,0.0009715931,0.000002188479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001247212,"about_ca_system_score_gemma":0.004460234,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01960666,"about_ca_topic_score_gemma":0.05070193,"domain_scores_codex":[0.9953501,0.0002706758,0.001294176,0.000961997,0.001363118,0.0007599248],"domain_scores_gemma":[0.9935138,0.001631128,0.0003520905,0.0003311652,0.003906343,0.0002654347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007855115,0.003541442,0.9714594,0.0002039976,0.0004175495,0.00006647953,0.0005671433,0.001509514,0.0005203249,0.000002818761,0.01118558,0.00267061],"study_design_scores_gemma":[0.009599197,0.007469109,0.9760627,0.0006433979,0.0002080068,0.000009009335,0.001859471,0.001717428,0.001715586,0.00005422662,0.000375275,0.0002865758],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896733,0.001593048,0.00003435308,0.001905084,0.0009381944,0.004066694,0.001607748,0.00005931212,0.0001222923],"genre_scores_gemma":[0.9865143,0.0002673275,0.006927401,0.0001082733,0.00158207,0.003924144,0.000227343,0.00008181325,0.0003673414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03109526,"threshold_uncertainty_score":0.9999518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07774063884718146,"score_gpt":0.4282145121325027,"score_spread":0.3504738732853212,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}