{"id":"W2145266626","doi":"10.1016/s1473-3099(13)70343-8","title":"Safety and efficacy of the peptide-based therapeutic vaccine for HIV-1, Vacc-4×: a phase 2 randomised, double-blind, placebo-controlled trial","year":2014,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Norges Forskningsråd","keywords":"Medicine; Immunogenicity; Placebo; ELISPOT; Viral load; Cart; Tolerability; Internal medicine; Clinical endpoint; Adjuvant; Clinical trial; Immunology; Human immunodeficiency virus (HIV); Adverse effect; T cell; Immune system; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003741389,0.002078942,0.003708117,0.0006485429,0.0004908724,0.001388931,0.001183511,0.003519525,0.007601008],"category_scores_gemma":[0.003244197,0.0009873637,0.001615602,0.0004626591,0.001758023,0.001629951,0.0004555148,0.002512987,0.001136808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000748049,"about_ca_system_score_gemma":0.001440994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004079834,"about_ca_topic_score_gemma":0.0006381384,"domain_scores_codex":[0.9984804,0.0008787745,0.0001048222,0.0002600803,0.0001313122,0.0001446799],"domain_scores_gemma":[0.9985682,0.0005304389,0.0003842203,0.00009978654,0.0001004816,0.0003168398],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9869484,0.003905822,0.0001543587,0.0004900905,0.0002443999,0.00001707021,0.00002665542,0.000110634,0.00163027,0.00005865039,0.0002303872,0.006183283],"study_design_scores_gemma":[0.9486189,0.05017737,0.0003471242,0.00002687217,0.0001249604,0.0000130275,0.000006606955,0.00012834,0.0001922888,0.000064315,0.000293393,0.000006866537],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9712522,0.00814031,0.001193649,0.0007719434,0.001075432,0.01375563,0.00126862,0.0001864246,0.002355904],"genre_scores_gemma":[0.9547206,0.006257738,0.004511802,0.001724424,0.00138299,0.02492937,0.00139524,0.00004515667,0.005032743],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007601008,"threshold_uncertainty_score":0.02542794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211420434049588,"score_gpt":0.3058646954114665,"score_spread":0.2837504910709707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}