{"id":"W2145266626","doi":"10.1016/s1473-3099(13)70343-8","title":"Safety and efficacy of the peptide-based therapeutic vaccine for HIV-1, Vacc-4×: a phase 2 randomised, double-blind, placebo-controlled trial","year":2014,"lang":"en","type":"article","venue":"The Lancet Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"Norges Forskningsråd","keywords":"Medicine; Immunogenicity; Placebo; ELISPOT; Viral load; Cart; Tolerability; Internal medicine; Clinical endpoint; Adjuvant; Clinical trial; Immunology; Human immunodeficiency virus (HIV); Adverse effect; T cell; Immune system; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006135407,0.0002152017,0.0007412906,0.00005966764,0.0004461049,0.00002793948,0.0002598328,0.00008587819,0.0001691474],"category_scores_gemma":[0.0004404936,0.0001031402,0.0003512185,0.0001095314,0.0001758206,0.00003369581,0.00005017851,0.0001658778,0.00004503065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003084699,"about_ca_system_score_gemma":0.0001186738,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003146597,"about_ca_topic_score_gemma":0.00003837394,"domain_scores_codex":[0.9982609,0.0007034023,0.0003442945,0.0002381121,0.0000634494,0.0003898056],"domain_scores_gemma":[0.9960803,0.003069773,0.0002088628,0.0005172386,0.00007813348,0.00004574029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9877132,0.001353411,0.001677149,0.00003653216,0.001009931,3.92169e-7,0.00006619218,0.00007209471,0.0009012388,0.0004134328,0.001342278,0.005414152],"study_design_scores_gemma":[0.9848763,0.00138943,0.001265864,0.00002388292,0.000771519,0.000005430461,0.00001066141,0.00007333227,0.001219892,0.0002877955,0.009958646,0.0001172539],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822826,0.002297318,0.001227962,0.001959131,0.0004166705,0.01029596,0.0003748037,0.0001156458,0.001029909],"genre_scores_gemma":[0.9974877,0.00009385883,0.000002928172,0.0002717105,0.0002151778,0.001297816,0.0001438827,0.00001857135,0.0004683039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01520515,"threshold_uncertainty_score":0.4205936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02211420434049588,"score_gpt":0.3058646954114665,"score_spread":0.2837504910709707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}