{"id":"W2145267805","doi":"10.1128/aac.03630-14","title":"Synergistic Combinations of the CCR5 Inhibitor VCH-286 with Other Classes of HIV-1 Inhibitors","year":2014,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de Santé Publique du Québec; Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Canadian Foundation for AIDS Research; Pfizer","keywords":"In vivo; Antagonism; Pharmacology; CCR5 receptor antagonist; Chemistry; Human immunodeficiency virus (HIV); In vitro; Enzyme inhibitor; Biology; Biochemistry; Virology; Receptor; Chemokine; Chemokine receptor; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005036223,0.0006684242,0.001065303,0.0004518825,0.000273318,0.0006056479,0.0006163054,0.0003231619,0.002822282],"category_scores_gemma":[0.000542679,0.0002560281,0.000491322,0.0003145363,0.0003545753,0.0003925691,0.0003888124,0.001063953,0.0005009765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002658696,"about_ca_system_score_gemma":0.0004683477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004693643,"about_ca_topic_score_gemma":0.001981624,"domain_scores_codex":[0.9993318,0.0002527543,0.00005754198,0.00007984557,0.0001535007,0.0001244903],"domain_scores_gemma":[0.9995487,0.0002005864,0.000054925,0.00006657375,0.00003671936,0.00009243695],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006368878,0.003676277,0.003110265,0.001367963,0.0003309188,0.0004457514,0.000123203,0.005485964,0.9195046,0.0006172584,0.0009617109,0.05800715],"study_design_scores_gemma":[0.0004502462,0.02310089,0.005136411,0.00005249069,0.0003515624,0.0008636183,0.00009196548,0.00271603,0.9582747,0.0001561839,0.008765454,0.00004046549],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759769,0.01330295,0.002911724,0.000296933,0.000312499,0.0004270044,0.0004440981,0.00007714679,0.006250836],"genre_scores_gemma":[0.9854917,0.005815764,0.005820045,0.0001026494,0.0001700617,0.0001109344,0.0003474859,0.00002364052,0.002117602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002822282,"threshold_uncertainty_score":0.009441495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008282033125371574,"score_gpt":0.2293443639922523,"score_spread":0.2210623308668808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}