{"id":"W2145273315","doi":"10.1529/biophysj.106.090514","title":"Phosphoinositides and Rho Proteins Spatially Regulate Actin Polymerization to Initiate and Maintain Directed Movement in a One-Dimensional Model of a Motile Cell","year":2006,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":130,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; National Science Foundation","keywords":"Cell biology; Motility; Biology; CDC42; Chemotaxis; Actin cytoskeleton; Cell polarity; Cytoskeleton; Actin; GTPase; Cell; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254017,0.0004450498,0.0005534659,0.0003946693,0.0008059522,0.001149175,0.0009020387,0.0008844964,0.001285678],"category_scores_gemma":[0.000230056,0.0005213112,0.0005797341,0.0003185069,0.001087074,0.0008539049,0.0006636603,0.0007370773,0.0002940255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008263218,"about_ca_system_score_gemma":0.0007628931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002210217,"about_ca_topic_score_gemma":0.003485486,"domain_scores_codex":[0.9998924,0.00001827414,0.000005731784,0.00002486957,0.00003502395,0.00002378479],"domain_scores_gemma":[0.9998868,0.00003041607,0.00002400675,0.00001240383,0.00001144108,0.00003496055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000340865,0.0001802283,0.0008047906,0.0001188628,0.00005546132,0.0005346383,0.0001700376,0.3287928,0.5630019,0.101797,0.0005795484,0.003623863],"study_design_scores_gemma":[0.0001631959,0.000184102,0.001172156,0.00000766706,0.000045867,0.0001750045,0.0001305599,0.9290963,0.05584313,0.01056463,0.002550191,0.00006725207],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9544718,0.000392702,0.03593529,0.0009719069,0.00009399875,0.00003452222,0.0001661496,0.0001313404,0.007802375],"genre_scores_gemma":[0.9814838,0.0003659384,0.01329696,0.00005161106,0.00001718671,0.00007364542,0.00006379823,0.00003158335,0.00461547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002210217,"threshold_uncertainty_score":0.005995452,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00748746364510412,"score_gpt":0.2079217575623493,"score_spread":0.2004342939172452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}