{"id":"W2145278311","doi":"10.1158/0008-5472.can-08-0676","title":"The Hypoxia-Activated ProDrug AQ4N Penetrates Deeply in Tumor Tissues and Complements the Limited Distribution of Mitoxantrone","year":2009,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"University Health Network","keywords":"Mitoxantrone; Prodrug; Cancer research; In vivo; Tumor hypoxia; Hypoxia (environmental); Chemistry; Drug; Pharmacology; Topoisomerase; Tumor microenvironment; Distribution (mathematics); Chemotherapy; Biology; Medicine; In vitro; Tumor cells; Biochemistry; Oxygen; Internal medicine; Radiation therapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001200561,0.0002908771,0.0002602934,0.0002536589,0.00009324413,0.0001446327,0.0001998634,0.000236931,0.0008562017],"category_scores_gemma":[0.0001272012,0.0001507904,0.0001864285,0.00008491285,0.0001440454,0.0002490142,0.0001566759,0.0002745795,0.0001523469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002588125,"about_ca_system_score_gemma":0.000135543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007929757,"about_ca_topic_score_gemma":0.0008777663,"domain_scores_codex":[0.9998888,0.00002355107,0.00001102092,0.00002665382,0.00003031048,0.00001970468],"domain_scores_gemma":[0.9999174,0.00001808265,0.00002496727,0.0000117106,0.00001507675,0.00001290759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000365908,0.000008177027,0.00008939627,0.00001490921,0.000001954436,0.00001598395,0.00000346173,0.00007581336,0.9989153,0.00001827816,0.000006577365,0.0008136305],"study_design_scores_gemma":[0.00001240159,0.000551552,0.001848532,0.000002209317,0.000009282739,0.0001489579,0.000007974818,0.001072153,0.9951727,0.00001698916,0.001154309,0.000002991567],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929964,0.0009821677,0.004872461,0.0000390659,0.00001159734,0.00004321574,0.00008400095,0.00005512054,0.0009159398],"genre_scores_gemma":[0.989129,0.0005905905,0.007618267,0.0000281217,0.00000781067,0.0000557166,0.0002044632,0.00001141206,0.002354717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008562017,"threshold_uncertainty_score":0.002864242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03786739809377082,"score_gpt":0.3631058923036818,"score_spread":0.325238494209911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}