{"id":"W2145281497","doi":"10.1093/carcin/bgr020","title":"Promoter methylation of Wnt antagonists<i>DKK1</i>and<i>SFRP1</i>is associated with opposing tumor subtypes in two large populations of colorectal cancer patients","year":2011,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Memorial University of Newfoundland; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Cancer Care Ontario","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; DKK1; Colorectal cancer; Microsatellite instability; DNA methylation; Methylation; Cancer research; Epigenetics; Biology; Internal medicine; Population; Carcinogenesis; Oncology; Cancer; Medicine; Genetics; Gene; Allele; Gene expression; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001781211,0.0001996947,0.0003006421,0.0005196022,0.0005755533,0.0004351155,0.0003235534,0.0002301016,0.001031528],"category_scores_gemma":[0.0005895661,0.0002387153,0.0002779183,0.0006515737,0.0004562043,0.0001298471,0.0003538972,0.0002452614,0.0001161742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001691669,"about_ca_system_score_gemma":0.0009679349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.3487422,"about_ca_topic_score_gemma":0.4433569,"domain_scores_codex":[0.9997851,0.00001730358,0.00001797065,0.00007844873,0.000048718,0.00005242709],"domain_scores_gemma":[0.9995068,0.00004233631,0.0002320056,0.00003934431,0.00006780262,0.0001116646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002029317,0.000006076699,0.9959518,0.000005849475,0.00003387042,0.00005974789,0.0001552494,0.00002102834,0.002531459,0.000009889396,0.00007872902,0.0009433514],"study_design_scores_gemma":[0.000003297396,0.00001286271,0.9996014,9.540798e-7,0.00001259166,0.00009717227,0.00006688757,0.00003394064,0.00007736978,0.000003461347,0.00008869804,0.000001426075],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993087,0.0001020311,0.00003718592,0.00002096329,9.480545e-7,0.000003798277,0.0003137288,0.00000283309,0.0002098304],"genre_scores_gemma":[0.9994215,0.0000533403,0.00002960895,0.000009722999,0.000001745014,0.000003360992,0.0003208988,0.000001341089,0.0001584231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3487422,"threshold_uncertainty_score":0.6934245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03854500163273054,"score_gpt":0.2917899432895997,"score_spread":0.2532449416568692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}