{"id":"W2145281497","doi":"10.1093/carcin/bgr020","title":"Promoter methylation of Wnt antagonists<i>DKK1</i>and<i>SFRP1</i>is associated with opposing tumor subtypes in two large populations of colorectal cancer patients","year":2011,"lang":"en","type":"article","venue":"Carcinogenesis","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Public Health Ontario; Memorial University of Newfoundland; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Cancer Care Ontario","funders":"National Cancer Institute; Canadian Institutes of Health Research","keywords":"Wnt signaling pathway; DKK1; Colorectal cancer; Microsatellite instability; DNA methylation; Methylation; Cancer research; Epigenetics; Biology; Internal medicine; Population; Carcinogenesis; Oncology; Cancer; Medicine; Genetics; Gene; Allele; Gene expression; Microsatellite","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001905736,0.0001817542,0.0004592817,0.0001822181,0.00004567227,0.000004204492,0.00007019673,0.00007068746,0.0001271174],"category_scores_gemma":[0.0001022377,0.000154642,0.00006637769,0.0004026331,0.000110255,0.0000612881,0.00004767124,0.00009467205,6.353969e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001782854,"about_ca_system_score_gemma":0.000171886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001419399,"about_ca_topic_score_gemma":0.001949517,"domain_scores_codex":[0.9986258,0.00008207135,0.0004268104,0.0002894235,0.0003186063,0.0002572503],"domain_scores_gemma":[0.9990415,0.00004393853,0.0002887897,0.0001553544,0.0003832713,0.00008715341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005138282,0.0003000145,0.9407908,0.0000894439,0.00007643359,0.000004908244,0.002562971,0.000007222267,0.05519824,0.00001609319,0.00001081056,0.000429269],"study_design_scores_gemma":[0.001573109,0.0004468671,0.628033,0.0001415387,0.0001588831,0.000002313731,0.00005392401,0.0001233989,0.369334,0.00003019208,0.000003556099,0.00009920924],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983352,0.0004378022,0.00001674927,0.00003034223,0.0001299357,0.0006889129,0.0001258507,0.00001771779,0.0002174319],"genre_scores_gemma":[0.9986354,0.00002051872,0.001097831,0.00006874408,0.00001517184,0.00006284151,0.00004453798,0.00003592883,0.00001903302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3141358,"threshold_uncertainty_score":0.6306117,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03854500163273054,"score_gpt":0.2917899432895997,"score_spread":0.2532449416568692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}