{"id":"W2145292441","doi":"10.1038/sj.emboj.7601115","title":"ATM–Chk2–p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency","year":2006,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health","keywords":"Biology; Embryonic stem cell; Carcinogenesis; DNA damage; Cell biology; Cancer research; Genome instability; Premature aging; Cancer; Genetics; Gene; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004787849,0.0001442684,0.0001391801,0.0000482444,0.0002283921,0.0000281159,0.0003244347,0.0000791352,0.0001068408],"category_scores_gemma":[0.00005002358,0.0001066307,0.0001111682,0.0001105434,0.00004061707,0.00001276724,0.0001046176,0.00009562558,0.000008784084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005436349,"about_ca_system_score_gemma":0.00007270295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003819802,"about_ca_topic_score_gemma":0.00002996563,"domain_scores_codex":[0.9987943,0.0001811226,0.0003028957,0.000202373,0.0002730693,0.0002462151],"domain_scores_gemma":[0.9991344,0.00001337539,0.0002858194,0.0003847405,0.0001114815,0.00007024635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001053464,0.000137324,0.000788213,0.000006703453,0.00002171818,0.000004583117,0.0001039116,0.0001553604,0.9949018,0.00007804922,0.000481234,0.003215783],"study_design_scores_gemma":[0.0003991556,0.000291065,0.006122831,0.00001617381,0.0000310481,0.000242112,0.0001437663,0.0000365019,0.9909748,0.000818492,0.0007911338,0.0001329127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974308,0.0004014246,0.001362801,0.00008831314,0.0001675392,0.0001244419,0.000007770926,0.00001057771,0.0004063299],"genre_scores_gemma":[0.9982677,0.0000993603,0.000631288,0.00005134463,0.000299627,0.000004855735,0.0000290956,0.00002800298,0.0005887564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005334618,"threshold_uncertainty_score":0.4348274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039505835098709,"score_gpt":0.2422901516885606,"score_spread":0.2318950933375735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}