{"id":"W2145309575","doi":"10.1002/smll.201001589","title":"Efficient Cytosolic Delivery of siRNA Using HDL‐Mimicking Nanoparticles","year":2011,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Cytosol; Nanoparticle; Nanotechnology; Biophysics; Chemistry; Materials science; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521006,0.0003093866,0.0002989777,0.0001530693,0.0001934172,0.0004637818,0.0001966058,0.000278628,0.0006538935],"category_scores_gemma":[0.0001197285,0.0001741535,0.0002173162,0.0001102544,0.0001645371,0.0002322522,0.0003653383,0.0003421884,0.0006608013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004276027,"about_ca_system_score_gemma":0.0003417456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006629233,"about_ca_topic_score_gemma":0.0006832806,"domain_scores_codex":[0.9999009,0.00001129049,0.000008451217,0.00003063076,0.00002771449,0.00002083649],"domain_scores_gemma":[0.9999524,0.00001002573,0.000009250944,0.000007162189,0.00001173982,0.000009422495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002515082,0.000006768967,0.00002610094,0.00003706098,0.00000196044,0.00004473658,0.00001485204,0.00006544482,0.9972154,0.0001752978,0.00008553297,0.002301626],"study_design_scores_gemma":[0.000008667837,0.00004752498,0.000142431,0.000002887492,0.000005274786,0.00006483788,0.000005721364,0.0008098841,0.9965833,0.00002477256,0.002302414,0.000002391463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9174913,0.004648032,0.06421823,0.0004391916,0.0001706415,0.0001404949,0.0003817448,0.0009124196,0.01159795],"genre_scores_gemma":[0.9726539,0.001793813,0.01587077,0.0001389093,0.00002744731,0.0000838037,0.0004131297,0.0001031302,0.008915015],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006629233,"threshold_uncertainty_score":0.003102481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05858845340644434,"score_gpt":0.2399974163063237,"score_spread":0.1814089628998794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}