{"id":"W2145309575","doi":"10.1002/smll.201001589","title":"Efficient Cytosolic Delivery of siRNA Using HDL‐Mimicking Nanoparticles","year":2011,"lang":"en","type":"article","venue":"Small","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research","funders":"","keywords":"Cytosol; Nanoparticle; Nanotechnology; Biophysics; Chemistry; Materials science; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000828482,0.00009904491,0.0001054897,0.00003660997,0.00003777598,0.000005763425,0.0001584483,0.00007389313,0.00003556375],"category_scores_gemma":[0.00001384151,0.00009392638,0.00008006499,0.00004554315,0.00006206876,0.0000012723,0.0001052439,0.0000386758,0.00001611032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000680796,"about_ca_system_score_gemma":0.00004483668,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001852108,"about_ca_topic_score_gemma":0.00004629484,"domain_scores_codex":[0.9993444,0.00002679332,0.0001793195,0.0001957517,0.0000606324,0.0001930933],"domain_scores_gemma":[0.9995617,0.000004043871,0.00007574051,0.0002324351,0.0000799645,0.00004610135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000617943,0.00006466794,0.003222015,0.00001087311,0.00003034199,0.000003511837,0.0002165261,0.0004728468,0.9946892,0.00002715164,0.00002363879,0.001177423],"study_design_scores_gemma":[0.0001784368,0.0001835455,0.002239251,0.00002350571,0.00002109708,0.00001097825,0.0001276446,0.001012185,0.9958979,0.00002568317,0.0001602336,0.0001194687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978438,0.0004529987,0.0004421166,0.000004026357,0.0001146732,0.00006259715,0.00000547852,0.000007388431,0.001066908],"genre_scores_gemma":[0.9981318,0.00003433566,0.001600932,0.00008641708,0.00006596197,0.000002407159,0.000004851086,0.00001248632,0.00006084343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001208761,"threshold_uncertainty_score":0.3830206,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05858845340644434,"score_gpt":0.2399974163063237,"score_spread":0.1814089628998794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}