{"id":"W2145335139","doi":"10.1158/1078-0432.ccr-14-0114","title":"Phase I Dose-Escalation Study of MEDI-573, a Bispecific, Antiligand Monoclonal Antibody against IGFI and IGFII, in Patients with Advanced Solid Tumors","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":61,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; Heart and Stroke Foundation of Canada","keywords":"Medicine; Tolerability; Adverse effect; Nausea; Pharmacokinetics; Internal medicine; Pharmacodynamics; Refractory (planetary science); Gastroenterology; Anorexia; Response Evaluation Criteria in Solid Tumors; Anemia; Pharmacology; Phases of clinical research; Toxicity","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002355051,0.0002352307,0.0008977182,0.0004387571,0.00011325,0.00002627801,0.0001940753,0.0001701186,0.00003578387],"category_scores_gemma":[0.001022543,0.0001748197,0.00007207765,0.0008575037,0.0005230915,0.0002051721,0.000141228,0.001016396,0.000007113303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008556929,"about_ca_system_score_gemma":0.0002670793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001799497,"about_ca_topic_score_gemma":0.0001292849,"domain_scores_codex":[0.995793,0.0004653302,0.001167421,0.0007223055,0.001277407,0.0005745711],"domain_scores_gemma":[0.9975517,0.0006024694,0.0002200076,0.0004977577,0.0006987295,0.0004292851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008395144,0.006924677,0.9454125,0.0001002444,0.00006862228,0.00002274502,0.0005406055,0.00001154401,0.002076575,0.00001059242,0.0002277996,0.03620902],"study_design_scores_gemma":[0.03392641,0.01707314,0.9459526,0.0003071836,0.0000348497,5.957584e-7,0.0004920247,0.0007594019,0.0009288633,0.00002808868,0.0003189812,0.0001778754],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997357,0.0001976117,0.00001378533,0.0002389077,0.000129917,0.001627276,0.00002156657,0.00002376248,0.0003902396],"genre_scores_gemma":[0.9990032,0.0004350236,0.00007212259,0.00009002973,0.000187524,0.00006171301,0.0000669583,0.00004210216,0.00004129043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03603115,"threshold_uncertainty_score":0.712894,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09062321050583509,"score_gpt":0.4891884358991357,"score_spread":0.3985652253933006,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}