{"id":"W2145347505","doi":"10.1093/nar/gkr1306","title":"The RNA helicase RHAU (DHX36) unwinds a G4-quadruplex in human telomerase RNA and promotes the formation of the P1 helix template boundary","year":2012,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada; Manitoba Health Research Council","keywords":"RNA; RNA Helicase A; Telomere; Biology; Nucleic acid structure; G-quadruplex; Gene knockdown; Helicase; Transcription (linguistics); Small interfering RNA; Cell biology; DNA; Molecular biology; Biophysics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001373325,0.000229059,0.000148356,0.0001405752,0.0001813275,0.0001960052,0.0001643668,0.0002140616,0.001155907],"category_scores_gemma":[0.0001594111,0.0001502811,0.0001692911,0.00009912398,0.0001824854,0.0001447286,0.0001361628,0.0002915607,0.0006629141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359005,"about_ca_system_score_gemma":0.0001706375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009131047,"about_ca_topic_score_gemma":0.001289443,"domain_scores_codex":[0.9998733,0.00002488164,0.00001034143,0.00003412008,0.00004176208,0.00001559303],"domain_scores_gemma":[0.9999386,0.00001295444,0.0000155358,0.000009001385,0.000004742967,0.00001921488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003289669,0.000007572359,0.00009868719,0.00001726092,0.000001846179,0.00002901968,0.000006950987,0.00005918011,0.9987965,0.00006179086,0.00001876867,0.0008695084],"study_design_scores_gemma":[0.000009568242,0.0001252741,0.002139629,0.000003065739,0.000005471451,0.0001573036,0.000006009465,0.0007691973,0.9953219,0.00003729158,0.001422812,0.000002439935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919673,0.00188792,0.00453597,0.0000918111,0.00002050136,0.00002836315,0.0002971779,0.0001569024,0.001014109],"genre_scores_gemma":[0.9898729,0.0006096635,0.004369607,0.00002922511,0.000009979032,0.00002007243,0.0009189202,0.00002015138,0.00414946],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001155907,"threshold_uncertainty_score":0.003866911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02971057904684558,"score_gpt":0.328339968118984,"score_spread":0.2986293890721384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}