{"id":"W2145355142","doi":"10.1371/journal.pone.0033003","title":"Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; Canadian Centre for Applied Research in Cancer Control; Occupational Cancer Research Centre; BC Cancer Agency","funders":"National Cancer Institute; Memorial Sloan-Kettering Cancer Center; National Human Genome Research Institute; Canadian Institutes of Health Research; Alvin J. Siteman Cancer Center; Canary Foundation","keywords":"KRAS; Genome instability; Adenocarcinoma; Lung cancer; Lung; Copy-number variation; Biology; Genome; Cancer research; Comparative genomic hybridization; Genetics; Gene; Bioinformatics; Pathology; Medicine; Internal medicine; Cancer; Mutation; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003176417,0.0001209459,0.000299383,0.000875379,0.0001982377,0.0003796818,0.0001196566,0.0002549792,0.001589195],"category_scores_gemma":[0.0009978494,0.0001467444,0.0002228832,0.000441638,0.0002396892,0.0001990781,0.0004504248,0.0001326456,0.0001639283],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001241783,"about_ca_system_score_gemma":0.0001383403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00099338,"about_ca_topic_score_gemma":0.002534447,"domain_scores_codex":[0.9996932,0.00005873423,0.00003568402,0.00008709736,0.00007667163,0.00004878437],"domain_scores_gemma":[0.9996402,0.0001359003,0.0001062131,0.00004238163,0.00002956551,0.00004573928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008879615,0.00004106701,0.8705129,0.00005166341,0.0002148659,0.0001869866,0.0003124763,0.00009394748,0.1141684,0.0001234283,0.00006978601,0.01333664],"study_design_scores_gemma":[0.000003378711,0.00007098357,0.9966852,0.000002361281,0.00002696433,0.0004682589,0.00009380614,0.0001182581,0.002280111,0.00009066219,0.000157951,0.000002001589],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989512,0.0003459662,0.0002075377,0.00001193781,0.000001279346,0.000004351698,0.0001880667,0.000006660934,0.0002828981],"genre_scores_gemma":[0.9992231,0.0001025831,0.000122259,0.00001225552,0.000002357867,0.000005216062,0.0003880254,0.000002759961,0.0001413337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001589195,"threshold_uncertainty_score":0.005316436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.044690415740239,"score_gpt":0.2721401976219872,"score_spread":0.2274497818817482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}