{"id":"W2145355142","doi":"10.1371/journal.pone.0033003","title":"Lung Adenocarcinoma of Never Smokers and Smokers Harbor Differential Regions of Genetic Alteration and Exhibit Different Levels of Genomic Instability","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia; Canadian Centre for Applied Research in Cancer Control; Occupational Cancer Research Centre; BC Cancer Agency","funders":"National Cancer Institute; Memorial Sloan-Kettering Cancer Center; National Human Genome Research Institute; Canadian Institutes of Health Research; Alvin J. Siteman Cancer Center; Canary Foundation","keywords":"KRAS; Genome instability; Adenocarcinoma; Lung cancer; Lung; Copy-number variation; Biology; Genome; Cancer research; Comparative genomic hybridization; Genetics; Gene; Bioinformatics; Pathology; Medicine; Internal medicine; Cancer; Mutation; DNA; DNA damage","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003852491,0.0001132748,0.0003558391,0.00007664278,0.00003203246,0.000003692209,0.00002693998,0.00005099768,0.00007958856],"category_scores_gemma":[0.00002291176,0.00009238852,0.00004319039,0.00004690491,0.0001407254,0.00008996297,0.00003362935,0.00005608889,2.539691e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006851235,"about_ca_system_score_gemma":0.00004996237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001208342,"about_ca_topic_score_gemma":0.000009727972,"domain_scores_codex":[0.9991904,0.00003448984,0.0003129446,0.0001530359,0.0001713945,0.0001377115],"domain_scores_gemma":[0.9994029,0.00004653844,0.0001498003,0.0002084812,0.00008140873,0.0001108967],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001124391,0.001226385,0.8146847,0.0006276839,0.000598374,5.404966e-7,0.001385931,0.000001049228,0.1808336,0.0002412706,0.000007039428,0.000280978],"study_design_scores_gemma":[0.001690591,0.0002343722,0.9474621,0.0001581599,0.001469301,0.000001968715,0.00009412026,0.0002978131,0.04848575,0.00003850866,0.000001298518,0.00006599331],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966907,0.002170729,0.0002526717,0.0001681593,0.00003011311,0.0005435096,0.0000929646,0.000007392,0.00004374057],"genre_scores_gemma":[0.9988425,0.0001502223,0.0008483125,0.0000203287,0.00004185302,0.00002328752,0.00001702162,0.000013398,0.00004308486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1327774,"threshold_uncertainty_score":0.3767494,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.044690415740239,"score_gpt":0.2721401976219872,"score_spread":0.2274497818817482,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}