{"id":"W2145420651","doi":"10.1371/journal.pbio.0060327","title":"BEAF Regulates Cell-Cycle Genes through the Controlled Deposition of H3K9 Methylation Marks into Its Conserved Dual-Core Binding Sites","year":2008,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Agence Nationale de la Recherche","keywords":"Chromatin; Biology; Cell biology; Genetics; Enhancer; Histone; DNA methylation; Gene; Transcription factor; Computational biology; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001387749,0.0001717312,0.000298435,0.00003501993,0.0002035693,0.000008235012,0.0001636132,0.0002566764,0.00001941171],"category_scores_gemma":[0.00008888384,0.0001266833,0.000129299,0.00007854466,0.0001875431,0.000004863019,0.0001120426,0.00007640327,0.000006103035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001489824,"about_ca_system_score_gemma":0.00004744734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004627825,"about_ca_topic_score_gemma":0.00005052254,"domain_scores_codex":[0.9989221,0.0001469436,0.0003649216,0.0002932195,0.00006572581,0.0002070914],"domain_scores_gemma":[0.9991731,0.00009372008,0.0002699478,0.0002965651,0.0001360482,0.00003061404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001798018,0.00007503048,0.003724821,0.00002941351,0.000140526,0.000001575889,0.0002156098,0.0002148345,0.9950317,0.0001910764,0.0000747102,0.0001208614],"study_design_scores_gemma":[0.001509575,0.000311851,0.0009649675,0.000009034567,0.00007115,0.0000264092,0.0001220098,0.005207036,0.9905998,0.0008071247,0.0001986733,0.0001723751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946907,0.003860829,0.0004056397,0.0001988648,0.00008794526,0.0003672637,0.00003435258,0.000012843,0.0003415639],"genre_scores_gemma":[0.9956362,0.001271943,0.002087724,0.0001100917,0.0001070297,0.00004127984,0.0005965629,0.00002007716,0.0001290932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004992202,"threshold_uncertainty_score":0.5165994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863364510746755,"score_gpt":0.240998080211146,"score_spread":0.2223644351036785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}