{"id":"W2145444267","doi":"10.1172/jci25888","title":" B-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer","year":2005,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":272,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health; Michael Smith Health Research BC; Avon Foundation for Women; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Defense","keywords":"Cancer research; MAPK/ERK pathway; Gene silencing; Biology; Breast cancer; Phenotype; Heat shock protein; Basal (medicine); Cancer; Kinase; Cell biology; Gene; Endocrinology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005458347,0.0001722784,0.0005435451,0.0001189429,0.00004010327,0.0000386561,0.0003895506,0.0005434698,0.000105804],"category_scores_gemma":[0.002216233,0.0001422491,0.0003595427,0.0001771784,0.0002956023,0.00003732277,0.0001273849,0.0009880593,0.00001675021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007070893,"about_ca_system_score_gemma":0.0009825593,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000709297,"about_ca_topic_score_gemma":0.0001430604,"domain_scores_codex":[0.9957636,0.0004520314,0.002511311,0.0003491276,0.0006078448,0.0003160617],"domain_scores_gemma":[0.9978375,0.0001641731,0.0008053528,0.0002968076,0.0003999186,0.0004962471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006757082,0.0005180489,0.9014496,0.00003605898,0.0001056565,0.00001228938,0.00004031215,0.0002386955,0.05817074,0.00001672007,0.006615137,0.03212109],"study_design_scores_gemma":[0.00690773,0.001123577,0.8917977,0.0003363769,0.00004804796,0.0001083672,0.00003604712,0.002864965,0.03984477,0.0002521634,0.0563391,0.0003411268],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9721749,0.0002528858,0.001007423,0.02582119,0.0003005161,0.0003112226,0.00003815365,0.000005375039,0.00008829122],"genre_scores_gemma":[0.985343,0.0006417019,0.005657902,0.005009729,0.002919599,0.0000160015,0.00001052235,0.00002778523,0.0003737708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04972397,"threshold_uncertainty_score":0.5800748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1414476706813646,"score_gpt":0.4501962148000962,"score_spread":0.3087485441187316,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}