{"id":"W2145476724","doi":"10.1093/hmg/ddn026","title":"Targeted delivery of an Mecp2 transgene to forebrain neurons improves the behavior of female Mecp2-deficient mice","year":2008,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Brain Institute; Toronto Western Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"MECP2; Rett syndrome; Forebrain; Biology; Transgene; Neuroscience; Genetically modified mouse; Phenotype; Endocrinology; Gene; Genetics; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001215975,0.0002678548,0.0002370543,0.00008716252,0.0001662605,0.00001070217,0.0005559615,0.0001266862,0.00001479926],"category_scores_gemma":[0.00001825015,0.0002473698,0.0001838554,0.0001855786,0.0002296578,0.000002725142,0.0001862672,0.00009672291,0.000002491133],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000076146,"about_ca_system_score_gemma":0.0001062305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003502924,"about_ca_topic_score_gemma":0.0000782581,"domain_scores_codex":[0.9982658,0.0001116432,0.0004618287,0.0004897971,0.0003269315,0.0003440242],"domain_scores_gemma":[0.9988388,0.000007101581,0.0001419392,0.0006945154,0.0001716296,0.0001460027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003787107,0.0002825801,0.0004911423,0.00001976333,0.00003950411,0.0000110022,0.0003687668,0.0009939104,0.9966964,0.00003872465,0.00007894536,0.0009413474],"study_design_scores_gemma":[0.0004589397,0.001104357,0.09438258,0.000005882163,0.00006213624,0.00002025213,0.0001607009,0.00005637127,0.9026458,0.00002610345,0.0008231405,0.0002537002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971343,0.001051958,0.0007326991,0.00003624377,0.00007771428,0.0007292022,0.00006530184,0.000009013363,0.0001636259],"genre_scores_gemma":[0.9960705,0.0001914808,0.002955171,0.0004234188,0.00001438224,0.00007691549,0.0001252326,0.00006189907,0.0000809814],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09405061,"threshold_uncertainty_score":0.9999979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157103191818954,"score_gpt":0.2424553280915445,"score_spread":0.226745008909649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}