{"id":"W2145489645","doi":"10.1016/j.ccr.2012.08.024","title":"Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma","year":2012,"lang":"en","type":"article","venue":"Cancer Cell","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":1864,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; SickKids Foundation; University of Toronto; Hospital for Sick Children; McGill University and Génome Québec Innovation Centre; Montreal Children's Hospital; McGill University Health Centre","funders":"Stichting Kinderen Kankervrij; Deutsche Krebshilfe; Bundesministerium für Bildung und Forschung; Brain Tumour Charity; Institute of Cancer Research; Deutsches Krebsforschungszentrum; Warren H. and Clara Cole Foundation; Genome Canada","keywords":"Glioblastoma; Epigenetics; IDH1; Biology; Epigenesis; Genetics; Cancer research; Isocitrate dehydrogenase; Gene; DNA methylation; Computational biology; Mutation; Gene expression; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002191092,0.0002183932,0.0004832344,0.001214487,0.0003333099,0.0004601692,0.0003332692,0.0003442746,0.0009964226],"category_scores_gemma":[0.0005217168,0.000133421,0.0002270529,0.0006660171,0.0004274108,0.0002559418,0.0005531618,0.0002228439,0.0001888086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004891264,"about_ca_system_score_gemma":0.0002660686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002572097,"about_ca_topic_score_gemma":0.004509851,"domain_scores_codex":[0.9997887,0.00001987218,0.00001972406,0.00003593343,0.00004795949,0.00008788663],"domain_scores_gemma":[0.9998139,0.00003126689,0.00006403074,0.00002166786,0.00002891924,0.00004029239],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002879164,0.0001439741,0.6078715,0.00006900881,0.0002159362,0.001502957,0.0008046853,0.0003556647,0.3590051,0.001026476,0.0006570871,0.02546836],"study_design_scores_gemma":[0.00004660622,0.0002986696,0.9733537,0.000007196836,0.0001028652,0.0040409,0.0008508204,0.0006168962,0.01853332,0.001081095,0.001055221,0.00001264714],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987437,0.0002632393,0.0002041537,0.00003302202,0.000003474414,0.0000105883,0.0001321459,0.000009832476,0.0005998339],"genre_scores_gemma":[0.9993656,0.00008346189,0.0001178072,0.00002688219,0.00000428632,0.000006350363,0.0002386971,0.000005705891,0.0001513299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002572097,"threshold_uncertainty_score":0.005114317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02284098826195404,"score_gpt":0.2769246861980719,"score_spread":0.2540836979361178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}