{"id":"W2145527433","doi":"10.1016/s0968-0896(00)00088-2","title":"Design, synthesis and cytotoxicity evaluation of 1-chloromethyl-5-hydroxy-1,2-dihydro-3H-benz[e]indole (seco-CBI) dimers","year":2000,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Indole test; Potency; Stereochemistry; Dimer; Cytotoxicity; Linker; Cell culture; Cancer cell lines; In vitro; Melanoma; Leukemia; Cancer cell; Cancer; Biochemistry; Cancer research; Immunology; Internal medicine; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002081036,0.0002247106,0.0002460963,0.0001799775,0.0002228435,0.0003127884,0.0005520515,0.0001984788,0.001409927],"category_scores_gemma":[0.0001584406,0.0001632639,0.0001439282,0.0001325559,0.0001515091,0.0001607149,0.000130609,0.0003332778,0.0005746114],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003882558,"about_ca_system_score_gemma":0.000233037,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005917027,"about_ca_topic_score_gemma":0.001049858,"domain_scores_codex":[0.9998626,0.00002746767,0.00001329109,0.00003874509,0.0000284593,0.0000294375],"domain_scores_gemma":[0.9999254,0.000007285139,0.00001950136,0.0000125367,0.00001612571,0.00001911892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002179399,0.00009118949,0.00008372145,0.000049899,0.000004962515,0.00003623333,0.00002707435,0.0006028974,0.9934247,0.0002653562,0.0001590723,0.005036968],"study_design_scores_gemma":[0.00004866484,0.000605177,0.0003601887,0.000003582871,0.00001261162,0.00008851728,0.00001220924,0.000917559,0.9947646,0.00002382719,0.00315852,0.000004640508],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696037,0.00440222,0.01555633,0.0002736506,0.0001105403,0.0004660122,0.0009303002,0.0002670465,0.008390226],"genre_scores_gemma":[0.9883811,0.001113813,0.004920599,0.00006570813,0.00001458941,0.000111887,0.000601799,0.00001906015,0.004771377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409927,"threshold_uncertainty_score":0.004716635,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03753559456596495,"score_gpt":0.2555378634713589,"score_spread":0.218002268905394,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}