{"id":"W2145571705","doi":"10.1110/ps.062358007","title":"Structure, interactions, and dynamics of the RING domain from human TRAF6","year":2007,"lang":"en","type":"article","venue":"Protein Science","topic":"NF-κB Signaling Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"Ubiquitin; Chemistry; Ring (chemistry); Nuclear magnetic resonance spectroscopy; Stereochemistry; Molecular dynamics; Helix (gastropod); Protein structure; Domain (mathematical analysis); Biophysics; Crystallography; Biochemistry; Biology; Computational chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003563228,0.00005657818,0.00004826307,0.00002698964,0.0001595191,0.00002056453,0.0002759599,0.00003032166,0.000005893587],"category_scores_gemma":[0.00007188448,0.00004216276,0.00001923883,0.0001291154,0.000386236,0.000005364585,0.0001484318,0.00006868281,2.363935e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001757657,"about_ca_system_score_gemma":0.00003938785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000812307,"about_ca_topic_score_gemma":0.0004534348,"domain_scores_codex":[0.9993864,0.00001521,0.0001176455,0.0002061508,0.0001451836,0.0001294313],"domain_scores_gemma":[0.9996042,0.000006405849,0.00007508642,0.0002362549,0.00004327675,0.00003480132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000005031487,0.000005810557,0.002123622,0.000002941041,0.000002151186,2.609669e-7,0.00006080304,0.000005463458,0.9953696,0.001060088,0.000001573527,0.00136272],"study_design_scores_gemma":[0.00008970255,0.00002610529,0.01011434,0.00001789443,0.000001899011,0.000003406881,0.00007394049,0.0000680624,0.9861748,0.003202295,0.0001734025,0.00005413007],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951614,0.0000740061,0.00409718,0.00004131948,0.000073902,0.0001389659,0.00001621289,0.000003866954,0.0003931726],"genre_scores_gemma":[0.995557,6.519796e-7,0.004316811,0.00002637872,0.0000425646,0.000002157043,0.000003831358,0.00000427754,0.00004628999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009194716,"threshold_uncertainty_score":0.1719348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008156988444782505,"score_gpt":0.2625644395759573,"score_spread":0.2544074511311747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}