{"id":"W2145604692","doi":"10.1007/s00280-006-0353-z","title":"Irinotecan–cisplatin interactions assessed in cell-based screening assays: cytotoxicity, drug accumulation and DNA adduct formation in an NSCLC cell line","year":2006,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; University of British Columbia Hospital; BC Cancer Agency; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Irinotecan; Cisplatin; Cytotoxicity; Drug; Cell culture; DNA; Cancer research; SN-38; Chemistry; Camptothecin; DNA adduct; Pharmacology; Biology; In vitro; Chemotherapy; Medicine; Cancer; Internal medicine; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006397296,0.0006665416,0.0008584608,0.0006359002,0.0005805434,0.0004984739,0.0004554407,0.0007041298,0.002269943],"category_scores_gemma":[0.0004771231,0.0003974415,0.000395506,0.0009182501,0.0003266578,0.0004848368,0.0003198479,0.0007304292,0.000764911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005258662,"about_ca_system_score_gemma":0.000563258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003420294,"about_ca_topic_score_gemma":0.005139753,"domain_scores_codex":[0.9989549,0.000381083,0.0001247354,0.000128304,0.0003258519,0.00008514529],"domain_scores_gemma":[0.9994317,0.0001762646,0.0000739907,0.000102661,0.0001631335,0.00005232939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002664753,0.0001990788,0.0008417633,0.00005755228,0.00003163186,0.0001011121,0.00008154312,0.0004012899,0.9962655,0.00005500871,0.00008727218,0.001611841],"study_design_scores_gemma":[0.00001429131,0.0007644864,0.003909818,0.000002597016,0.00003044261,0.0001614611,0.00003654095,0.0009550906,0.993637,0.00001251361,0.0004687947,0.000006971683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990306,0.001187095,0.004990607,0.0001123,0.00003668163,0.0001599445,0.0009808906,0.0001413769,0.002085101],"genre_scores_gemma":[0.9849011,0.001121815,0.00696419,0.0000661493,0.00001156338,0.000211724,0.001678747,0.00003207468,0.005012543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003420294,"threshold_uncertainty_score":0.007593751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020654306366584,"score_gpt":0.3436383977097108,"score_spread":0.3134318546460449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}