{"id":"W2145619523","doi":"10.1093/schbul/sbr189","title":"Dopamine D2 Receptor Occupancy and Cognition in Schizophrenia: Analysis of the CATIE Data","year":2012,"lang":"en","type":"article","venue":"Schizophrenia Bulletin","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Medical Research Council; Medical Research Council; Lundbeck Canada; Otsuka Pharmaceutical; National Institutes of Health; Shionogi; Eisai; Astellas Pharma; AstraZeneca; Kanae Foundation for the Promotion of Medical Science; Sanofi; Government of Canada; Kyowa Hakko Kirin; GlaxoSmithKline; Canadian Institutes of Health Research; H. Lundbeck A/S; Sunovion; Dainippon Sumitomo Pharma; Pfizer; CHDI Foundation; Eli Lilly and Company; Japanese Society of Clinical Neuropsychopharmacology; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health","keywords":"Antipsychotic; Neurocognitive; Dopamine receptor D2; Psychology; Olanzapine; Vigilance (psychology); Psychosis; Ziprasidone; Schizophrenia (object-oriented programming); Risperidone; Population; Clinical psychology; Psychiatry; Medicine; Cognition; Dopamine; Neuroscience; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008315314,0.0003207005,0.0007456745,0.0006282056,0.0001313069,0.00003036116,0.0004247982,0.0001569032,0.001111581],"category_scores_gemma":[0.000670531,0.0002204957,0.0001856334,0.00162762,0.0002817931,0.0001391791,0.0005259013,0.000481324,0.0001424704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008899297,"about_ca_system_score_gemma":0.0002162963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003204911,"about_ca_topic_score_gemma":0.0006227118,"domain_scores_codex":[0.9972792,0.0002579127,0.0006045396,0.0005716198,0.0006664376,0.000620277],"domain_scores_gemma":[0.9974712,0.0002769732,0.0002156033,0.001537085,0.0001273074,0.0003718808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0437949,0.002736056,0.8614724,0.0003043852,0.004432267,0.00004139721,0.0003918789,0.000005288476,0.004134782,0.002774321,0.00907663,0.07083567],"study_design_scores_gemma":[0.009784682,0.0001896787,0.9805316,0.0001989256,0.00235579,0.00003815481,0.0001215499,0.000200288,0.002254659,0.0001131407,0.003941657,0.0002698654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897621,0.004211622,0.00001847175,0.00400072,0.0001905893,0.0007885487,0.0004517639,0.00004424869,0.0005319109],"genre_scores_gemma":[0.9918078,0.0003955963,0.006336247,0.0001317661,0.0002303816,0.0000675867,0.0007739679,0.0000346274,0.0002220784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1190592,"threshold_uncertainty_score":0.9998015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03398723708101234,"score_gpt":0.2998696902701421,"score_spread":0.2658824531891297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}