{"id":"W2145619523","doi":"10.1093/schbul/sbr189","title":"Dopamine D2 Receptor Occupancy and Cognition in Schizophrenia: Analysis of the CATIE Data","year":2012,"lang":"en","type":"article","venue":"Schizophrenia Bulletin","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute of Mental Health; National Medical Research Council; Medical Research Council; Lundbeck Canada; Otsuka Pharmaceutical; National Institutes of Health; Shionogi; Eisai; Astellas Pharma; AstraZeneca; Kanae Foundation for the Promotion of Medical Science; Sanofi; Government of Canada; Kyowa Hakko Kirin; GlaxoSmithKline; Canadian Institutes of Health Research; H. Lundbeck A/S; Sunovion; Dainippon Sumitomo Pharma; Pfizer; CHDI Foundation; Eli Lilly and Company; Japanese Society of Clinical Neuropsychopharmacology; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health","keywords":"Antipsychotic; Neurocognitive; Dopamine receptor D2; Psychology; Olanzapine; Vigilance (psychology); Psychosis; Ziprasidone; Schizophrenia (object-oriented programming); Risperidone; Population; Clinical psychology; Psychiatry; Medicine; Cognition; Dopamine; Neuroscience; Environmental health","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01052155,0.00049662,0.001804763,0.001713235,0.0003061567,0.001064414,0.0007231279,0.0005305047,0.002820415],"category_scores_gemma":[0.02323482,0.0002645295,0.002631858,0.00249597,0.0003419248,0.0004271539,0.001309251,0.0007977503,0.0003096947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006973174,"about_ca_system_score_gemma":0.001344491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007175234,"about_ca_topic_score_gemma":0.01088109,"domain_scores_codex":[0.9927999,0.003757918,0.0009372887,0.0009543988,0.001282385,0.0002680823],"domain_scores_gemma":[0.9746483,0.01634202,0.004935458,0.00246981,0.001198452,0.000405856],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02362853,0.0002996486,0.906772,0.002640995,0.01825283,0.0004488572,0.0002242083,0.01079566,0.00170213,0.0006611032,0.008359427,0.02621464],"study_design_scores_gemma":[0.001586997,0.001849473,0.9709712,0.0003120646,0.004238814,0.000627553,0.0001827965,0.008463502,0.0006553764,0.0003905039,0.0106422,0.00007949693],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9089563,0.003609456,0.001800669,0.0003904828,0.00002385479,0.0003598779,0.08334398,0.00008585658,0.00142954],"genre_scores_gemma":[0.9204775,0.0007382456,0.001885484,0.0001321277,0.00002010737,0.0006652703,0.07555883,0.00002548984,0.0004969679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01052155,"threshold_uncertainty_score":0.05564392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03398723708101234,"score_gpt":0.2998696902701421,"score_spread":0.2658824531891297,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}