{"id":"W2145636146","doi":"10.2174/0929867322666151021111016","title":"Hypoxia Activated Prodrugs: Factors Influencing Design and Development","year":2015,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Prodrug; Hypoxia (environmental); Pharmacology; Chemotherapy; Cancer cell; Cancer research; Tumor hypoxia; Cancer; Biology; Medicine; Chemistry; Oxygen; Radiation therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002532357,0.0005102852,0.0007569341,0.00004657454,0.00008491438,0.00003178267,0.0002685784,0.0002858536,0.00002544886],"category_scores_gemma":[0.0001511378,0.0003813493,0.0001023927,0.0001147248,0.0001215914,0.000004320371,0.0002269936,0.0004031175,0.00001310139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002425639,"about_ca_system_score_gemma":0.002207869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006422081,"about_ca_topic_score_gemma":0.00000102804,"domain_scores_codex":[0.9980574,0.00007249905,0.0003869759,0.0006508996,0.0004033545,0.0004288815],"domain_scores_gemma":[0.9988419,0.00002674493,0.0002149403,0.0003423732,0.0001139368,0.0004600823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003837064,0.00008556221,0.00002841081,0.01014118,0.0003281235,0.00001383222,0.00009654951,3.043452e-7,0.001946967,8.169026e-8,0.002599333,0.9847213],"study_design_scores_gemma":[0.0004412562,0.00006642477,0.000004058295,0.003792448,0.0001704999,0.000050563,0.00004522063,3.105378e-7,0.01824867,0.000001811351,0.9768211,0.0003576301],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.003882339,0.9952024,0.00006083494,0.00000229444,0.0001157495,0.0005700389,0.00002694343,0.00001939177,0.0001200708],"genre_scores_gemma":[0.000478642,0.997182,0.0001459401,0.000003547282,0.0003180598,0.0001893649,0.001407955,0.00005113278,0.0002234321],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9843637,"threshold_uncertainty_score":0.9998639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1195864755359582,"score_gpt":0.3883792530081532,"score_spread":0.268792777472195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}