{"id":"W2145636146","doi":"10.2174/0929867322666151021111016","title":"Hypoxia Activated Prodrugs: Factors Influencing Design and Development","year":2015,"lang":"en","type":"review","venue":"Current Medicinal Chemistry","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Prodrug; Hypoxia (environmental); Pharmacology; Chemotherapy; Cancer cell; Cancer research; Tumor hypoxia; Cancer; Biology; Medicine; Chemistry; Oxygen; Radiation therapy; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008590639,0.0005660261,0.000421424,0.0004147836,0.0001838783,0.000914256,0.0004975109,0.0007240602,0.001674601],"category_scores_gemma":[0.001167579,0.000419771,0.000288094,0.0005157428,0.0002729459,0.001320707,0.0003412092,0.0009945745,0.001241333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006657544,"about_ca_system_score_gemma":0.0005344712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004957888,"about_ca_topic_score_gemma":0.0007037058,"domain_scores_codex":[0.9996738,0.00007548192,0.0000407459,0.00006526078,0.00009598816,0.00004875041],"domain_scores_gemma":[0.9997278,0.0001009917,0.00006565246,0.00001186117,0.00007113945,0.00002252877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005093658,0.0003164408,0.001179097,0.01185407,0.00008677227,0.00138539,0.0003941607,0.01150525,0.5087549,0.04609609,0.005702078,0.4122165],"study_design_scores_gemma":[0.0001354705,0.003794319,0.002318421,0.001321743,0.000182463,0.00254744,0.0001801078,0.004440103,0.4213584,0.008394639,0.5552356,0.0000914439],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1846889,0.673021,0.08458312,0.003321755,0.001039417,0.001232617,0.0008628751,0.0004154426,0.05083499],"genre_scores_gemma":[0.3537254,0.5636129,0.06342197,0.001399653,0.0004101827,0.0009714466,0.0008130576,0.0001383224,0.01550713],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001674601,"threshold_uncertainty_score":0.005602062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1195864755359582,"score_gpt":0.3883792530081532,"score_spread":0.268792777472195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}