{"id":"W2145637828","doi":"10.1093/neuonc/4.4.242","title":"Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentiallyregulate expression of vascular endothelial growth factor in human malignantastrocytoma cells","year":2002,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Toronto Western Hospital; Hospital for Sick Children","funders":"National Cancer Institute; Heart and Stroke Foundation of Canada","keywords":"Angiogenesis; MAPK/ERK pathway; Vascular endothelial growth factor; Cancer research; Kinase; Biology; Cell growth; Signal transduction; Vascular endothelial growth factor A; Cell culture; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001098995,0.0001875194,0.0001882522,0.0002066895,0.000145335,0.0002456918,0.0000850734,0.0001378665,0.0005020605],"category_scores_gemma":[0.0001265631,0.0001503166,0.0001671772,0.0001905612,0.0001554443,0.00009918035,0.0001010801,0.0001771082,0.0002162329],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002871042,"about_ca_system_score_gemma":0.0002314378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008582624,"about_ca_topic_score_gemma":0.001361123,"domain_scores_codex":[0.999862,0.00002075924,0.00001402159,0.00002012097,0.000040148,0.00004286328],"domain_scores_gemma":[0.9999359,0.00001317419,0.00001157518,0.00001088974,0.00001081493,0.00001765853],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000204072,0.00003041915,0.0004526611,0.00001974132,0.000004440722,0.00006462239,0.00002540573,0.00004615096,0.9980129,0.0001052539,0.00003192329,0.001002421],"study_design_scores_gemma":[0.00003786695,0.0006044604,0.01370193,0.0000033593,0.00003022142,0.0004726172,0.00004861869,0.0008388564,0.9811662,0.00006620572,0.003024263,0.000005434983],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965389,0.001172793,0.0008517184,0.00003494639,0.00001833127,0.00001272906,0.0001527834,0.00002291038,0.001195016],"genre_scores_gemma":[0.9960282,0.001011107,0.00127707,0.00003309113,0.000009657715,0.00004530801,0.0003467056,0.000006695748,0.001242247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008582624,"threshold_uncertainty_score":0.002083063,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112069211047521,"score_gpt":0.2398972368662729,"score_spread":0.2286903157615208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}