{"id":"W2145637828","doi":"10.1093/neuonc/4.4.242","title":"Phosphatidylinositol 3'-kinase and MAPK/ERK kinase 1/2 differentiallyregulate expression of vascular endothelial growth factor in human malignantastrocytoma cells","year":2002,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; SickKids Foundation; Toronto Western Hospital; Hospital for Sick Children","funders":"National Cancer Institute; Heart and Stroke Foundation of Canada","keywords":"Angiogenesis; MAPK/ERK pathway; Vascular endothelial growth factor; Cancer research; Kinase; Biology; Cell growth; Signal transduction; Vascular endothelial growth factor A; Cell culture; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008510421,0.0002902133,0.0004863578,0.0001195251,0.00008198098,0.00001632201,0.000238259,0.0003222433,0.0001449817],"category_scores_gemma":[0.00004948317,0.000279136,0.000154079,0.00009157455,0.0001709747,0.00001015436,0.0002100011,0.0001878025,0.000004390769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002680967,"about_ca_system_score_gemma":0.00004660582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004528841,"about_ca_topic_score_gemma":0.0000660919,"domain_scores_codex":[0.9981418,0.0002333226,0.0004377741,0.0005888719,0.0001812298,0.0004169603],"domain_scores_gemma":[0.9991275,0.00004498745,0.0002101911,0.0003854882,0.00006576836,0.0001660594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001695025,0.0003211595,0.001509425,0.00005478498,0.00002226676,0.00004128513,0.0001748189,0.000007748677,0.9919901,0.00003765575,0.001080793,0.004590467],"study_design_scores_gemma":[0.003219445,0.0007710034,0.00415619,0.00002300926,0.0000428508,0.00002730297,0.00002775618,0.00002888506,0.9438702,0.00002610134,0.04757553,0.000231725],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962596,0.001894222,0.0001155552,0.00005073732,0.0009304518,0.0003743444,0.0001038731,0.00001568834,0.0002554894],"genre_scores_gemma":[0.9964656,0.002181142,0.0002650932,0.0002014471,0.0006621752,0.00004052505,0.00003583141,0.00004187772,0.0001063056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0481199,"threshold_uncertainty_score":0.9999661,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112069211047521,"score_gpt":0.2398972368662729,"score_spread":0.2286903157615208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}