{"id":"W2145651831","doi":"10.3899/jrheum.141366","title":"The Need for Preclinical Biomarkers in Systemic Autoimmune Rheumatic Diseases","year":2015,"lang":"en","type":"letter","venue":"The Journal of Rheumatology","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"","keywords":"Autoantibody; Medicine; Immunology; Autoimmunity; Disease; Rheumatoid arthritis; Anti-nuclear antibody; Immune system; Proinflammatory cytokine; Immune dysregulation; Autoimmune disease; Serology; Antibody; Pathology; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03100636,0.001841332,0.003850795,0.003491302,0.0007855061,0.007611601,0.003242497,0.005972689,0.005667451],"category_scores_gemma":[0.05161687,0.00104002,0.0009777588,0.001887977,0.003678864,0.0100535,0.003312752,0.01061105,0.003197811],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002209429,"about_ca_system_score_gemma":0.004784883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001336817,"about_ca_topic_score_gemma":0.00102803,"domain_scores_codex":[0.9888355,0.005442265,0.001343053,0.001285954,0.002587985,0.0005051674],"domain_scores_gemma":[0.9065927,0.05171435,0.009315892,0.007385089,0.02097025,0.00402163],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001905333,0.001144693,0.06098165,0.008201252,0.0004551841,0.001498618,0.0005321844,0.002918168,0.01648852,0.0805632,0.06153701,0.7637741],"study_design_scores_gemma":[0.0004401552,0.00378498,0.03570317,0.01298636,0.0007516604,0.00661329,0.001186797,0.008168839,0.01292205,0.1256496,0.7913873,0.0004058939],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.02233046,0.8069566,0.06296102,0.07436432,0.01172315,0.0006259112,0.001338996,0.001116265,0.01858328],"genre_scores_gemma":[0.3348259,0.3723163,0.1765804,0.06870568,0.0338728,0.002256432,0.004353823,0.000515693,0.006573067],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.03100636,"threshold_uncertainty_score":0.1639792,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04612702922454748,"score_gpt":0.3434568480806968,"score_spread":0.2973298188561493,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}