{"id":"W2145705090","doi":"10.1161/atvbaha.111.237941","title":"Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis","year":2011,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Endoplasmic reticulum; GSK-3; Glycogen synthase; Unfolded protein response; Apolipoprotein B; Chemistry; Glycogen; Kinase; Internal medicine; Cell biology; Endocrinology; Biology; Medicine; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005683792,0.001364744,0.0006721728,0.00138538,0.0003340247,0.0005447286,0.0003919592,0.0008137038,0.001501435],"category_scores_gemma":[0.0001516595,0.0004560009,0.000641362,0.0005819807,0.0004539231,0.000386918,0.0003617137,0.001195874,0.0004883243],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003970187,"about_ca_system_score_gemma":0.0003739002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003425807,"about_ca_topic_score_gemma":0.0008224381,"domain_scores_codex":[0.999599,0.00009355447,0.00005463691,0.00008295774,0.00009523332,0.00007454361],"domain_scores_gemma":[0.9996612,0.00001598644,0.0001571882,0.00003436027,0.00003015632,0.0001011268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002992376,0.0006585698,0.001422763,0.00009681402,0.00004156805,0.0004230701,0.00004474242,0.0001035525,0.9913524,0.0002040562,0.0001134013,0.002546693],"study_design_scores_gemma":[0.001303501,0.01056642,0.06288181,0.000160738,0.0003951658,0.004966346,0.0003377032,0.002623561,0.9086995,0.0007024546,0.007300187,0.0000625984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936103,0.001879425,0.002517111,0.0002031061,0.00005533312,0.00009751951,0.0004116762,0.0001544213,0.001071159],"genre_scores_gemma":[0.9824593,0.003239443,0.005849411,0.0002278587,0.00005416462,0.0004318922,0.001098321,0.00007132535,0.006568375],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001501435,"threshold_uncertainty_score":0.005022824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04772301455275731,"score_gpt":0.2556255899892048,"score_spread":0.2079025754364474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}