{"id":"W2145740217","doi":"10.1038/pr.2014.183","title":"Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy","year":2014,"lang":"en","type":"article","venue":"Pediatric Research","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Heart, Lung, and Blood Institute; National Institutes of Health; Hospital for Sick Children; American Heart Association","keywords":"Medicine; Dilated cardiomyopathy; Internal medicine; Cardiology; Heart failure; Ejection fraction; Cardiomyopathy; Beta blocker; Genotype; Hemodynamics; Cohort; Vascular resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005459587,0.0003001106,0.0002468186,0.0003884593,0.0001946241,0.000325412,0.0001893659,0.0003303309,0.00141302],"category_scores_gemma":[0.001893455,0.0001470461,0.0002922837,0.0004198281,0.0002322221,0.0002170358,0.0001945577,0.0003717634,0.0001799777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001997649,"about_ca_system_score_gemma":0.0002152891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002156853,"about_ca_topic_score_gemma":0.00234061,"domain_scores_codex":[0.999669,0.0001222023,0.00003137772,0.0000628381,0.0000497115,0.00006497851],"domain_scores_gemma":[0.9985971,0.0004280549,0.0006719134,0.00004317268,0.00007440841,0.0001854538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007011479,0.000012277,0.9991426,0.000002782546,0.00001133366,0.00006306051,0.00002113385,0.00002016085,0.000198948,0.000004725129,0.00002357352,0.0004292853],"study_design_scores_gemma":[0.000006074425,0.00009850832,0.9990591,0.000004737245,0.00001780477,0.0005136585,0.00006816773,0.00007265675,0.00008837373,0.000008187943,0.00006132343,0.000001294633],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996002,0.0001592027,0.00004034942,0.00002251593,0.000001987567,0.000001956573,0.00007983374,0.000001261899,0.00009253107],"genre_scores_gemma":[0.9996505,0.00007712266,0.00009576985,0.00001367272,0.000004726968,0.000003503456,0.0001155627,0.000001144175,0.0000380341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002156853,"threshold_uncertainty_score":0.004727006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01072696617631453,"score_gpt":0.2697613649786542,"score_spread":0.2590343988023397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}