{"id":"W2145741262","doi":"10.1091/mbc.e11-02-0114","title":"Evidence for a fence that impedes the diffusion of phosphatidylinositol 4,5-bisphosphate out of the forming phagosomes of macrophages","year":2011,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":75,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Institute of General Medical Sciences; National Institutes of Health; Mechanobiology Institute, Singapore; National University of Singapore","keywords":"Fluorescence recovery after photobleaching; Phagosome; Phosphatidylinositol; Exocytosis; Biology; Biophysics; Membrane; Cell biology; Photobleaching; Phosphatidylinositol 4,5-bisphosphate; Phagocytosis; Fluorescence; Fluorescence microscope; Kinase; Biochemistry; Optics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003070706,0.0001630608,0.0002629109,0.00002040946,0.00007837924,0.000001929558,0.0008047493,0.000168527,0.00001157261],"category_scores_gemma":[0.00007738692,0.00008647509,0.0004238504,0.00008516655,0.0006173189,0.000004858776,0.0002065653,0.00007382684,2.013123e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004499119,"about_ca_system_score_gemma":0.00006360887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001041794,"about_ca_topic_score_gemma":0.00002749658,"domain_scores_codex":[0.9989592,0.0001091581,0.0003809125,0.0002326951,0.0001275768,0.0001904606],"domain_scores_gemma":[0.9985533,0.00005381513,0.0005697522,0.0006651523,0.0001355778,0.00002240117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002363449,0.00007166751,0.02478518,0.0001571405,0.0000575444,2.547785e-7,0.000510037,0.00001102019,0.9734905,0.0001770469,0.000008064567,0.0004952009],"study_design_scores_gemma":[0.0004030279,0.0002811827,0.00774549,0.0001152934,0.000121416,0.000001520603,0.0001456947,0.00003852415,0.990321,0.0004997883,0.0002361919,0.00009086734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975957,0.01017313,0.0128307,0.0000833954,0.0002579268,0.0005551002,0.00003916126,0.000002417165,0.0001011501],"genre_scores_gemma":[0.9983961,0.000804971,0.00052962,0.0000524295,0.00001466764,0.00001849622,0.00003144141,0.00001484531,0.0001374144],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0224391,"threshold_uncertainty_score":0.3526352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03401191390629684,"score_gpt":0.2627193736728382,"score_spread":0.2287074597665414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}