{"id":"W2145775566","doi":"10.1093/glycob/cwn002","title":"Composite active site of chondroitin lyase ABC accepting both epimers of uronic acid","year":2008,"lang":"en","type":"article","venue":"Glycobiology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute; McGill University","funders":"Canadian Institutes of Health Research; National Institute of Agricultural Biotechnology","keywords":"Chemistry; Lyase; Stereochemistry; Active site; Chondroitin sulfate; Chondroitin; Epimer; Enantiomer; Racemization; Uronic acid; Biochemistry; Enzyme; Glycosaminoglycan; Polysaccharide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006210111,0.0002395544,0.0003375021,0.0002190092,0.0001620214,0.0003000383,0.0003296618,0.0003665588,0.001403184],"category_scores_gemma":[0.000137222,0.0001103045,0.0002592517,0.0001888599,0.0001344893,0.0001881453,0.0001596065,0.0002197433,0.0007247073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003985585,"about_ca_system_score_gemma":0.0002762972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001140728,"about_ca_topic_score_gemma":0.0006216078,"domain_scores_codex":[0.9998909,0.00001104989,0.000006649243,0.00004105547,0.00003290413,0.00001738266],"domain_scores_gemma":[0.9999075,0.000008355824,0.00001843567,0.000009762057,0.00002068931,0.00003520981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002246519,0.00003604819,0.001928992,0.00008560639,0.00001439702,0.0001930342,0.00003457034,0.000262083,0.9903195,0.0003824123,0.0001280378,0.006390724],"study_design_scores_gemma":[0.0001021664,0.0005888839,0.08260453,0.00003050601,0.00008970629,0.002641133,0.0001550793,0.01320987,0.8830779,0.0005193156,0.01694785,0.00003290657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837908,0.002277382,0.01088453,0.0000860485,0.00002891192,0.00004468175,0.0004388852,0.0001886797,0.00225999],"genre_scores_gemma":[0.9885156,0.0002019343,0.008012988,0.00004068218,0.000009458598,0.00002069521,0.001161612,0.00001017576,0.002026898],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001403184,"threshold_uncertainty_score":0.004694104,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485575910943253,"score_gpt":0.2648793263114095,"score_spread":0.250023567201977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}