{"id":"W2145775566","doi":"10.1093/glycob/cwn002","title":"Composite active site of chondroitin lyase ABC accepting both epimers of uronic acid","year":2008,"lang":"en","type":"article","venue":"Glycobiology","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Biotechnology Research Institute; McGill University","funders":"Canadian Institutes of Health Research; National Institute of Agricultural Biotechnology","keywords":"Chemistry; Lyase; Stereochemistry; Active site; Chondroitin sulfate; Chondroitin; Epimer; Enantiomer; Racemization; Uronic acid; Biochemistry; Enzyme; Glycosaminoglycan; Polysaccharide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001920724,0.0002247774,0.0004262871,0.0001330135,0.0001113309,0.000003495298,0.0003601247,0.0002873278,0.0001348664],"category_scores_gemma":[0.0001199557,0.000212817,0.0001920613,0.0002002003,0.0006840504,0.00000767229,0.0002748658,0.0002140601,0.00001840581],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002651736,"about_ca_system_score_gemma":0.0002204375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002526196,"about_ca_topic_score_gemma":0.00006074784,"domain_scores_codex":[0.9982462,0.0001809558,0.000437542,0.0004707796,0.0001518975,0.0005126218],"domain_scores_gemma":[0.9989043,0.00004270507,0.0002622101,0.0005054554,0.0001692148,0.0001160518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007338257,0.0001127587,0.0115671,0.00003828329,0.0001172095,0.00001954492,0.000140958,0.00002674242,0.9822227,0.00004991415,0.0003888479,0.004582152],"study_design_scores_gemma":[0.001251491,0.001041433,0.01680292,0.00001829986,0.00001977444,0.0001497048,0.00007463404,0.00003405537,0.9734148,0.00002921509,0.006938846,0.0002248063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955465,0.001086367,0.00049766,0.00006502282,0.0001170295,0.0002934894,0.0002392674,0.00001159859,0.002143128],"genre_scores_gemma":[0.997395,0.0005953895,0.001030633,0.00009400972,0.000130011,0.00002782872,0.0003385676,0.0000266725,0.0003618197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008807845,"threshold_uncertainty_score":0.8678424,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485575910943253,"score_gpt":0.2648793263114095,"score_spread":0.250023567201977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}