{"id":"W2145796537","doi":"10.1093/hmg/ddp352","title":"p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR","year":2009,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":96,"is_retracted":false,"has_abstract":true,"ca_institutions":"Agricultural Research Institute of Ontario; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; FightSMA; Muscular Dystrophy Association; Eli Lilly and Company; Spinal Muscular Atrophy Foundation","keywords":"SMN1; Anisomycin; Biology; Spinal muscular atrophy; SMA*; Protein kinase A; Cell biology; Molecular biology; Messenger RNA; Protein biosynthesis; Gene; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008941122,0.0002700949,0.0001199076,0.0001729107,0.0002540706,0.0001325791,0.00009218945,0.0001378415,0.00125083],"category_scores_gemma":[0.0001234513,0.00007502967,0.0001952099,0.00005527525,0.0001771465,0.0001389577,0.0001473477,0.000289162,0.0004279091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001848637,"about_ca_system_score_gemma":0.0001055376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001570587,"about_ca_topic_score_gemma":0.00040592,"domain_scores_codex":[0.9999194,0.00001949946,0.000004444994,0.00001470796,0.00002114296,0.00002086619],"domain_scores_gemma":[0.9999514,0.00001413815,0.00001339471,0.000005700569,0.000006499125,0.000008842148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005397521,0.0000103336,0.00008416834,0.00002060106,0.000001591416,0.00008701546,0.000008605327,0.00002790728,0.9984722,0.00007531659,0.00003933943,0.001119117],"study_design_scores_gemma":[0.000008408752,0.0001948639,0.002352568,0.000003293587,0.000004335329,0.0003147168,0.00001711568,0.0003812389,0.9946868,0.00008157043,0.001953217,0.000001767443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863825,0.004124155,0.005436603,0.0002827312,0.00007508424,0.0000299792,0.000157714,0.0001651342,0.003346104],"genre_scores_gemma":[0.9924247,0.001242819,0.003362554,0.00004150136,0.00003646263,0.00002610687,0.0001824431,0.00001350333,0.002669872],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00125083,"threshold_uncertainty_score":0.004184425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03508099445791159,"score_gpt":0.32251572546417,"score_spread":0.2874347310062584,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}