{"id":"W2145828377","doi":"10.1093/hmg/ddu450","title":"Association of exome sequences with plasma C-reactive protein levels in >9000 participants","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Human Genome Research Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Exome sequencing; Exome; Genetics; Minor allele frequency; Genome-wide association study; HNF1A; Genetic association; Biology; Candidate gene; Allele; Allele frequency; Single-nucleotide polymorphism; Phenotype; Gene; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007560451,0.0003085848,0.0003746843,0.0003376751,0.0003704966,0.0008315437,0.0002633239,0.0005007343,0.00386546],"category_scores_gemma":[0.002318385,0.000181332,0.0002448136,0.0007577369,0.000237937,0.0002954232,0.0005979748,0.000374178,0.0005527128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002021402,"about_ca_system_score_gemma":0.0001826853,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003299693,"about_ca_topic_score_gemma":0.004423909,"domain_scores_codex":[0.9994962,0.0001226029,0.00004820238,0.0002121935,0.00006846525,0.00005219859],"domain_scores_gemma":[0.9993612,0.000205802,0.0001860128,0.00007898942,0.0000889001,0.00007912325],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002246525,0.0001295503,0.9786358,0.0001094231,0.0003428813,0.0002965135,0.0004589773,0.0002406499,0.006223548,0.0002351429,0.002522902,0.008558077],"study_design_scores_gemma":[0.0001308329,0.000215415,0.9928874,0.00002490375,0.0001697429,0.0006655648,0.0002255446,0.0007314252,0.0008659608,0.0002506669,0.003819216,0.00001326631],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935869,0.0001813727,0.0002713986,0.00007659486,0.000007956463,0.0000201462,0.005451657,0.000007973387,0.0003960907],"genre_scores_gemma":[0.9855172,0.0002437115,0.001109173,0.0001898366,0.00001988813,0.000122411,0.01085207,0.00002280203,0.001922934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00386546,"threshold_uncertainty_score":0.01293123,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257470312385347,"score_gpt":0.2800408737411582,"score_spread":0.2542938425026235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}