{"id":"W2145828377","doi":"10.1093/hmg/ddu450","title":"Association of exome sequences with plasma C-reactive protein levels in >9000 participants","year":2014,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Human Genome Research Institute; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institute on Aging; National Cancer Institute; National Institutes of Health","keywords":"Exome sequencing; Exome; Genetics; Minor allele frequency; Genome-wide association study; HNF1A; Genetic association; Biology; Candidate gene; Allele; Allele frequency; Single-nucleotide polymorphism; Phenotype; Gene; Medicine; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002520259,0.0001338269,0.0002855662,0.0001105465,0.00003401138,0.00001146039,0.00007334614,0.00007819577,0.00004610356],"category_scores_gemma":[0.0001902536,0.0001160149,0.00004650916,0.0001546368,0.00006645,0.0000408126,0.0000155941,0.00008014886,0.000008671383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005913899,"about_ca_system_score_gemma":0.0001234118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003387462,"about_ca_topic_score_gemma":0.0001211435,"domain_scores_codex":[0.9987395,0.0001055812,0.000309207,0.0001944535,0.0004000773,0.0002511337],"domain_scores_gemma":[0.9992236,0.00002505328,0.000228474,0.0002338992,0.00018262,0.00010638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001163049,0.0003128824,0.1455934,0.000181572,0.0002316142,0.00004140674,0.001313844,0.0009717552,0.8468614,0.002621131,0.00003454733,0.001720159],"study_design_scores_gemma":[0.002016536,0.0003698723,0.7230025,0.0001911301,0.0002708028,0.00000381487,0.00009097659,0.0005006792,0.2709901,0.001073433,0.001306964,0.0001832203],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968396,0.0001303115,0.0005006696,0.0000832264,0.00002084031,0.0004808536,0.000008831727,0.00002016343,0.001915506],"genre_scores_gemma":[0.9981952,0.000004867494,0.001019874,0.00006604647,0.00006280562,0.00005498009,0.00002197893,0.00002081673,0.0005534707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5774091,"threshold_uncertainty_score":0.4730949,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0257470312385347,"score_gpt":0.2800408737411582,"score_spread":0.2542938425026235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}