{"id":"W2145857178","doi":"10.1073/pnas.0914888107","title":"An endocardial pathway involving Tbx5, Gata4, and Nos3 required for atrial septum formation","year":2010,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":76,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; University of Ottawa; Université de Montréal","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Haploinsufficiency; GATA4; Transcription factor; Phenotype; Atrial septum; Cell biology; Biology; Gene; Cell; Medicine; Internal medicine; Cancer research; Endocrinology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001109235,0.00005829774,0.00007703424,0.00006577653,0.0001715047,0.00003293746,0.0003251173,0.00009289551,0.000002056596],"category_scores_gemma":[0.0008612081,0.00004267984,0.00007037818,0.0001498794,0.0004148392,0.00006603615,0.0001189565,0.00009238929,2.32615e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005613907,"about_ca_system_score_gemma":0.00004685021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002439077,"about_ca_topic_score_gemma":8.643622e-7,"domain_scores_codex":[0.9990827,0.000006055829,0.00016532,0.0001822768,0.0004349446,0.0001286762],"domain_scores_gemma":[0.9994995,0.00004572425,0.0001233027,0.00001007972,0.0002817487,0.00003961634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003225419,0.000008694118,0.00123357,0.00003469268,0.000005954372,1.137749e-9,0.00004823638,0.000003062913,0.9932968,0.003566523,0.0001163972,0.001653816],"study_design_scores_gemma":[0.0002939314,0.0001772481,0.006364462,0.00001031784,0.00000535774,0.000006903334,0.0000710607,0.00151423,0.9841177,0.006440907,0.0009374226,0.00006046044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986178,0.000103594,0.000004179149,0.000315369,0.0000339877,0.0002672129,0.00003179083,0.000003263005,0.0006228157],"genre_scores_gemma":[0.9984056,0.00001472168,0.001212536,0.00004662764,0.000267633,0.00001116001,0.000001553408,0.000003458807,0.00003668434],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009179099,"threshold_uncertainty_score":0.1740433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03756716196921213,"score_gpt":0.3365511793699021,"score_spread":0.29898401740069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}