{"id":"W2145869597","doi":"10.7554/elife.07296","title":"Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Waterloo; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation","keywords":"Folding (DSP implementation); Lead (geology); Protein folding; Proteostasis; Cell biology; SOD1; Chemistry; Biology; Biophysics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238005,0.00008550571,0.00009534294,0.00002481882,0.00003718443,0.00001262178,0.00008184222,0.00009320158,0.00000218441],"category_scores_gemma":[0.0001059207,0.00007639849,0.00002645864,0.00006138906,0.00002443348,0.000003363612,0.00008436761,0.00004672324,0.000003314577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005821654,"about_ca_system_score_gemma":0.0000579092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008464212,"about_ca_topic_score_gemma":0.00001048806,"domain_scores_codex":[0.9994782,0.00001815317,0.0001232568,0.0001566602,0.00009774628,0.000125988],"domain_scores_gemma":[0.9995956,0.000004617485,0.00004678061,0.0001645947,0.00009865136,0.00008972297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004880299,0.000005337156,0.0005226545,0.000007289748,0.00001798432,0.000001053026,0.0002410907,0.0004701497,0.9956904,0.0002501255,0.000848532,0.001896558],"study_design_scores_gemma":[0.0005555921,0.0002322978,0.004645421,0.00002170493,0.00002085711,0.00001174349,0.0002332626,0.000670249,0.9800104,0.0002920532,0.01307292,0.0002334739],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938635,0.001150075,0.003592156,0.0001006309,0.00009369872,0.0001118541,0.00002026759,0.00000864814,0.001059151],"genre_scores_gemma":[0.9949151,0.00002905609,0.004433385,0.0002774508,0.0001618478,0.00000709544,0.00003280799,0.00001121508,0.0001320642],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01568,"threshold_uncertainty_score":0.311544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636827254711818,"score_gpt":0.258448005171911,"score_spread":0.2420797326247928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}