{"id":"W2145869597","doi":"10.7554/elife.07296","title":"Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways","year":2015,"lang":"en","type":"article","venue":"eLife","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Waterloo; University of Toronto","funders":"Canadian Institutes of Health Research; University of Toronto; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation","keywords":"Folding (DSP implementation); Lead (geology); Protein folding; Proteostasis; Cell biology; SOD1; Chemistry; Biology; Biophysics; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289451,0.0001746952,0.0001622971,0.00008538957,0.000151551,0.0002912203,0.0001927039,0.0001381057,0.0005605921],"category_scores_gemma":[0.0002853775,0.0001797592,0.0001495382,0.00006480463,0.0002616953,0.0002787776,0.0002038431,0.0004573933,0.00009900024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002531484,"about_ca_system_score_gemma":0.0001065039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004227603,"about_ca_topic_score_gemma":0.0004785112,"domain_scores_codex":[0.9999446,0.000007653416,0.000003391143,0.00001745575,0.00001417294,0.00001284602],"domain_scores_gemma":[0.9999087,0.00002184137,0.00002286203,0.0000123172,0.0000135604,0.00002069746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004236002,0.00006453877,0.004771932,0.00003414467,0.00002433614,0.0001511553,0.0001864068,0.003668173,0.9858235,0.001016839,0.0001705089,0.003664712],"study_design_scores_gemma":[0.00006724301,0.00056909,0.07419877,0.00001475846,0.00005428736,0.0004292725,0.0003684258,0.1238958,0.7960109,0.003325699,0.001005274,0.00006055835],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984751,0.00006068539,0.001200622,0.00002988494,0.000002921308,0.000002521656,0.00002534836,0.00002362453,0.00017909],"genre_scores_gemma":[0.999353,0.00003950231,0.0004181368,0.00001188289,0.000001586228,0.000003808119,0.00004310366,0.000007923552,0.0001210438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005605921,"threshold_uncertainty_score":0.001875341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01636827254711818,"score_gpt":0.258448005171911,"score_spread":0.2420797326247928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}