{"id":"W2145893833","doi":"10.1074/jbc.275.7.4840","title":"MAN1, an Inner Nuclear Membrane Protein That Shares the LEM Domain with Lamina-associated Polypeptide 2 and Emerin","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":337,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Ottawa Regional Cancer Foundation; University of Ottawa","funders":"National Cancer Institute; American Liver Foundation; National Institutes of Health; Medical Research Council Canada; National Center for Research Resources; Centre National de la Recherche Scientifique; Medical Research Council","keywords":"Emerin; Nuclear lamina; Inner membrane; Biology; Integral membrane protein; Nucleoporin; Nuclear pore; Membrane protein; Nuclear protein; Molecular biology; Nuclear localization sequence; Cell biology; Cytoplasm; Cell nucleus; Genetics; Gene; Nuclear transport; Membrane; Mitochondrion","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000648685,0.000309636,0.0001032381,0.0002235945,0.0002549338,0.0002413685,0.0001263022,0.0002471841,0.001036769],"category_scores_gemma":[0.000131673,0.00008350503,0.0001314747,0.0001456256,0.0001568112,0.0002207366,0.0001431379,0.0002297278,0.0006005127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002593411,"about_ca_system_score_gemma":0.0001518209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000399274,"about_ca_topic_score_gemma":0.0006292543,"domain_scores_codex":[0.9999604,0.000003950467,0.000001834417,0.00001436209,0.00001034036,0.000009080907],"domain_scores_gemma":[0.9999264,0.000007851561,0.00002984709,0.00000499517,0.000009327339,0.00002160736],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001023171,0.00001741534,0.003778988,0.00005147882,0.00001104017,0.0005275726,0.00004596861,0.00007823314,0.9882677,0.0002814732,0.0001677919,0.006670043],"study_design_scores_gemma":[0.00002146088,0.0004937389,0.1347032,0.00002373619,0.00005712738,0.01649954,0.0001356122,0.001719233,0.8148171,0.0006262513,0.03087752,0.00002550792],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918903,0.002607557,0.002754215,0.0001181903,0.00002493681,0.00001356453,0.0002915569,0.0001193715,0.002180314],"genre_scores_gemma":[0.9843653,0.001435217,0.004602833,0.0000824141,0.00001623528,0.0000129513,0.001665586,0.00001413698,0.007805312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001036769,"threshold_uncertainty_score":0.003468335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008535789965267996,"score_gpt":0.2009891785252689,"score_spread":0.1924533885600009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}