{"id":"W2145918716","doi":"10.1128/aac.49.5.1782-1786.2005","title":"Mutations in PA3574 ( <i>nalD</i> ) Lead to Increased MexAB-OprM Expression and Multidrug Resistance in Laboratory and Clinical Isolates of <i>Pseudomonas aeruginosa</i>","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cystic Fibrosis Foundation","keywords":"Pseudomonas aeruginosa; Microbiology; Multiple drug resistance; Pseudomonadales; Efflux; Pseudomonadaceae; Biology; Mutation; Drug resistance; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192052,0.0004148947,0.0002410351,0.0003928132,0.0001883846,0.0003505962,0.0002163191,0.0004290082,0.001417465],"category_scores_gemma":[0.0005354576,0.000180941,0.0003296583,0.0002900989,0.0003854191,0.000124032,0.0002275887,0.0005089687,0.0005293619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003103974,"about_ca_system_score_gemma":0.0002600959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001391184,"about_ca_topic_score_gemma":0.001105274,"domain_scores_codex":[0.9996099,0.00009330653,0.00004216048,0.00005882245,0.0001265028,0.00006925599],"domain_scores_gemma":[0.9997205,0.00006957728,0.00009458962,0.00002596704,0.00002511228,0.00006420263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001577387,0.0001174256,0.001413963,0.00002996498,0.00001520955,0.00044731,0.0000238067,0.00009263305,0.9955037,0.0001153687,0.0002514746,0.001831482],"study_design_scores_gemma":[0.0001075708,0.001387243,0.03902086,0.00001596222,0.00007203907,0.008176723,0.000121748,0.001181956,0.9454471,0.0001490539,0.004293355,0.00002651057],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977847,0.0002869636,0.0006854969,0.0001595766,0.00001546958,0.00002368836,0.0003406451,0.00006667533,0.0006367934],"genre_scores_gemma":[0.9974282,0.0001476855,0.001149499,0.00006831232,0.0000128367,0.00002032971,0.0005976806,0.00002394129,0.0005514844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001417465,"threshold_uncertainty_score":0.004741848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007262521873760064,"score_gpt":0.2579064135655391,"score_spread":0.250643891691779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}