{"id":"W2145918716","doi":"10.1128/aac.49.5.1782-1786.2005","title":"Mutations in PA3574 ( <i>nalD</i> ) Lead to Increased MexAB-OprM Expression and Multidrug Resistance in Laboratory and Clinical Isolates of <i>Pseudomonas aeruginosa</i>","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":139,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Cystic Fibrosis Foundation","keywords":"Pseudomonas aeruginosa; Microbiology; Multiple drug resistance; Pseudomonadales; Efflux; Pseudomonadaceae; Biology; Mutation; Drug resistance; Bacteria; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001680022,0.0001468991,0.0002313964,0.00006639201,0.00003623092,0.00001777537,0.00008611583,0.0002335232,0.000004759839],"category_scores_gemma":[0.00002070302,0.0001377803,0.0000267276,0.0001039786,0.0001612823,0.000007457545,0.00008258731,0.00009782682,5.514739e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005562513,"about_ca_system_score_gemma":0.00002729323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006743835,"about_ca_topic_score_gemma":0.0008081918,"domain_scores_codex":[0.9990286,0.00005361947,0.0003362409,0.0003636992,0.00003950398,0.0001783516],"domain_scores_gemma":[0.9996472,0.00001659571,0.00008332938,0.0001551506,0.00003414713,0.00006355784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002561713,0.0001599448,0.04191581,0.00001945521,0.00001333296,0.000001695971,0.0001313579,0.000001577007,0.9528019,0.000006263422,0.001071305,0.003621166],"study_design_scores_gemma":[0.002691899,0.0001577642,0.08854539,0.00008840915,0.000008036342,0.000003257094,0.00003988394,0.00002710547,0.8717649,0.00002044472,0.03643662,0.0002162825],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975312,0.0003520354,0.00002197003,0.001770827,0.00003554178,0.0002053675,0.0000479083,0.000005392759,0.00002970811],"genre_scores_gemma":[0.9884568,0.004918782,0.003870021,0.002600028,0.00006503705,0.000004772019,0.00002501388,0.00001571951,0.0000437667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08103701,"threshold_uncertainty_score":0.5618519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007262521873760064,"score_gpt":0.2579064135655391,"score_spread":0.250643891691779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}