{"id":"W2145943124","doi":"10.1128/aac.00113-13","title":"Identification and Characterization of a Novel HIV-1 Nucleotide-Competing Reverse Transcriptase Inhibitor Series","year":2013,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Reverse transcriptase; Resistance mutation; Nucleotidyltransferase; Biology; Primer (cosmetics); Reverse-transcriptase inhibitor; Virology; Polymerase; Viral replication; Virus; Recombinant DNA; Nucleotide; Enzyme; Molecular biology; Polymerase chain reaction; Chemistry; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001416189,0.0003905573,0.0003554027,0.0004668728,0.000174236,0.0003107737,0.0003397767,0.0002426568,0.001807597],"category_scores_gemma":[0.0001856315,0.0001372443,0.0002506069,0.0003284051,0.0001425832,0.0002689468,0.0001694247,0.0004624543,0.0006598076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002385822,"about_ca_system_score_gemma":0.000415993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006176861,"about_ca_topic_score_gemma":0.001148334,"domain_scores_codex":[0.999916,0.000008783332,0.000008574796,0.00002058109,0.00003030566,0.0000158626],"domain_scores_gemma":[0.999896,0.00001616607,0.00001640204,0.000008352048,0.00002700889,0.00003593667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001205625,0.0002647898,0.0004639723,0.000149176,0.00001781242,0.0002035497,0.00002851388,0.0008287739,0.9836151,0.00037197,0.0002857825,0.01365004],"study_design_scores_gemma":[0.0002849168,0.007441795,0.006971918,0.00005971715,0.0001529682,0.001870409,0.00004051538,0.00348199,0.9447262,0.0002962152,0.03462408,0.00004930831],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9531507,0.01200549,0.01662358,0.0003530399,0.00008857995,0.0009370726,0.002793107,0.0002078218,0.01384052],"genre_scores_gemma":[0.9503506,0.01014466,0.02248934,0.0005112855,0.00009158302,0.0003481898,0.0049905,0.00005717003,0.01101666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001807597,"threshold_uncertainty_score":0.00604701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009971801753501637,"score_gpt":0.2215484239756706,"score_spread":0.211576622222169,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}