{"id":"W2145947303","doi":"10.1136/thoraxjnl-2011-201197","title":"Fixing cystic fibrosis CFTR with correctors and potentiators. Off to a good start","year":2011,"lang":"en","type":"editorial","venue":"Thorax","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Cystic fibrosis; Potentiator; Cystic fibrosis transmembrane conductance regulator; Medicine; Ivacaftor; Genetic enhancement; Epithelial sodium channel; Transfection; Phenotype; Bioinformatics; Cell biology; Gene; Internal medicine; Immunology; Biology; Genetics; Chemistry; Sodium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001877709,0.0007769839,0.001575778,0.0008451963,0.0004515413,0.001250734,0.0008458513,0.003765423,0.008925393],"category_scores_gemma":[0.001693449,0.0003025283,0.001130493,0.0004316439,0.001044595,0.001702459,0.0007314407,0.003806117,0.00233137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004962866,"about_ca_system_score_gemma":0.0003861341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005402943,"about_ca_topic_score_gemma":0.0006962247,"domain_scores_codex":[0.999413,0.0001649941,0.00004410699,0.00008039825,0.0002394414,0.0000580016],"domain_scores_gemma":[0.99939,0.0003062741,0.00008607526,0.000052631,0.00007544956,0.00008959463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.02536439,0.003041005,0.0006996577,0.005208706,0.000330834,0.0003498393,0.000174218,0.0002354604,0.04992284,0.007389516,0.02708118,0.8802023],"study_design_scores_gemma":[0.0386401,0.09355012,0.008730145,0.007540526,0.001202538,0.003492589,0.0005027551,0.001029411,0.08686899,0.01301113,0.7451526,0.0002791619],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"editorial","genre_scores_codex":[0.06414364,0.8648025,0.006054995,0.03248803,0.01215447,0.001140664,0.0007961931,0.0008573621,0.01756232],"genre_scores_gemma":[0.281929,0.5863768,0.02082353,0.05896188,0.01158997,0.001249204,0.001249891,0.0002914067,0.03752825],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.008925393,"threshold_uncertainty_score":0.02985847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01058632274480654,"score_gpt":0.2830341608410005,"score_spread":0.272447838096194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}