{"id":"W2145975911","doi":"10.1016/s0167-4889(02)00161-1","title":"Calyculin A-induced endothelial cell shape changes are independent of [Ca2+]i elevation and may involve actin polymerization","year":2002,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Croucher Foundation","keywords":"Staurosporine; Myosin light-chain kinase; Bleb (medicine); Cell biology; Biology; Kinase; Microtubule polymerization; Protein kinase inhibitor; Protein kinase C; Phosphorylation; Protein kinase A; Tubulin; Microtubule","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001673793,0.0005991029,0.0005976289,0.0004622379,0.000511478,0.000710187,0.000417095,0.0006054536,0.001824273],"category_scores_gemma":[0.0004156966,0.0003479908,0.0005055838,0.0005003852,0.000439736,0.0004813362,0.0003211434,0.001466499,0.0006475717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008662516,"about_ca_system_score_gemma":0.0004216547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00259674,"about_ca_topic_score_gemma":0.004187717,"domain_scores_codex":[0.9997678,0.00004164771,0.00002239971,0.000027243,0.00006268432,0.00007814235],"domain_scores_gemma":[0.9996457,0.00007347174,0.00006154645,0.00007942841,0.0000519637,0.00008793115],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006656534,0.00008525606,0.0001387078,0.00006539883,0.00002243915,0.000258213,0.00002546863,0.0000887753,0.9963093,0.0002816265,0.0002111597,0.001847952],"study_design_scores_gemma":[0.00012068,0.0002208076,0.01130797,0.000008614269,0.0000205913,0.0002096814,0.00005357934,0.0007322631,0.9850936,0.000113574,0.002109371,0.000009270132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9797514,0.004180182,0.00413524,0.0006413988,0.0003995668,0.0001312143,0.001573457,0.0003856207,0.008801983],"genre_scores_gemma":[0.9904492,0.001938564,0.002227158,0.0002339688,0.00007312159,0.0001393654,0.0009794086,0.00006075408,0.003898465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00259674,"threshold_uncertainty_score":0.006285131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04345764504298891,"score_gpt":0.293977853544818,"score_spread":0.250520208501829,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}