{"id":"W2145985597","doi":"10.1128/iai.00222-07","title":"Neisserial Outer Membrane Vesicles Bind the Coinhibitory Receptor Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 and Suppress CD4 <sup>+</sup> T Lymphocyte Function","year":2007,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Sanofi Pasteur; Sanofi","keywords":"Biology; Bacterial outer membrane; Bacterial adhesin; Neisseria meningitidis; Neisseria; Microbiology; Antigen; Vesicle; Membrane protein; Cell biology; Bacteria; Immunology; Biochemistry; Membrane; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000884617,0.0004069917,0.000205352,0.0000880128,0.0001141316,0.0003337029,0.0001481263,0.0003074392,0.0008349455],"category_scores_gemma":[0.0001834271,0.000110849,0.0001727915,0.00004837119,0.0001741666,0.0001667639,0.0002184073,0.0004071624,0.0003258217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001947888,"about_ca_system_score_gemma":0.0001557168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004750539,"about_ca_topic_score_gemma":0.000645294,"domain_scores_codex":[0.9998715,0.00002674785,0.000005464251,0.00001237802,0.00003202419,0.00005183664],"domain_scores_gemma":[0.9999326,0.00002052717,0.00001440743,0.000009555203,0.000009446476,0.00001337559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007846923,0.00002679653,0.000187667,0.00002305179,0.000004299166,0.00002769786,0.000009005687,0.00003248871,0.9978058,0.0001040841,0.00003015456,0.001670478],"study_design_scores_gemma":[0.00002105628,0.0004903731,0.003930021,0.000006239057,0.00001193408,0.0002139002,0.00003221216,0.0005745579,0.9928717,0.00005072702,0.001795238,0.000002021932],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946252,0.002576896,0.001276058,0.00004863594,0.00002255608,0.00001645646,0.00003565952,0.00002452122,0.001374117],"genre_scores_gemma":[0.9965827,0.0008952664,0.0008012047,0.00003491268,0.00001602985,0.00001658426,0.0001084797,0.000006302182,0.001538564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008349455,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009952049038308446,"score_gpt":0.2163258565147543,"score_spread":0.2063738074764459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}