{"id":"W2145985597","doi":"10.1128/iai.00222-07","title":"Neisserial Outer Membrane Vesicles Bind the Coinhibitory Receptor Carcinoembryonic Antigen-Related Cellular Adhesion Molecule 1 and Suppress CD4 <sup>+</sup> T Lymphocyte Function","year":2007,"lang":"en","type":"article","venue":"Infection and Immunity","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Sanofi Pasteur; Sanofi","keywords":"Biology; Bacterial outer membrane; Bacterial adhesin; Neisseria meningitidis; Neisseria; Microbiology; Antigen; Vesicle; Membrane protein; Cell biology; Bacteria; Immunology; Biochemistry; Membrane; Gene; Escherichia coli","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000658193,0.0002484313,0.0002550475,0.0001652052,0.001012766,0.00007814321,0.00007607629,0.0003974786,0.0005949484],"category_scores_gemma":[0.00005189083,0.0001908416,0.00009155624,0.0002221641,0.0002319368,0.0002644225,0.0001100215,0.0004174605,0.0001103469],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005290044,"about_ca_system_score_gemma":0.00003999596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002161777,"about_ca_topic_score_gemma":0.00009077056,"domain_scores_codex":[0.9985481,0.0004346494,0.0003808338,0.0002825378,0.00002851878,0.0003253936],"domain_scores_gemma":[0.9992605,0.0001446718,0.0001408722,0.0003035727,0.0001054051,0.00004493729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005243947,0.00009739895,0.005896986,0.00002192178,0.0001264782,7.733403e-7,0.0004782869,0.0000103852,0.9875371,0.0001123727,0.0004033811,0.004790525],"study_design_scores_gemma":[0.002919432,0.0005089887,0.161021,0.00004274524,0.0001071798,0.0001526342,0.0004219394,0.00004757192,0.775635,0.00004655277,0.05878619,0.0003107988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946753,0.002063102,0.0001006197,0.00008769937,0.002319426,0.0003113821,0.00001292535,0.0001280239,0.0003015373],"genre_scores_gemma":[0.998122,0.0009358196,0.000004925736,0.00006791984,0.0001880004,0.00001145955,0.0001378113,0.00002386874,0.0005082231],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2119021,"threshold_uncertainty_score":0.7789478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009952049038308446,"score_gpt":0.2163258565147543,"score_spread":0.2063738074764459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}