{"id":"W2145999869","doi":"10.2353/ajpath.2008.070494","title":"Cleavage of Type II Collagen by Cathepsin K in Human Osteoarthritic Cartilage","year":2008,"lang":"en","type":"article","venue":"American Journal Of Pathology","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":100,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; Merck Canada Inc. (Canada); Université de Montréal; Shriners Hospitals for Children - Canada; McGill University","funders":"","keywords":"Cartilage; Cathepsin; Type II collagen; Collagenase; Cathepsin K; Chemistry; Aggrecan; Matrix metalloproteinase; Extracellular matrix; Collagen, type I, alpha 1; Osteoarthritis; Molecular biology; Cell biology; Biochemistry; Pathology; Medicine; Biology; Anatomy; In vitro; Enzyme; Articular cartilage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004012174,0.0002802377,0.0002563806,0.0004501439,0.0002359913,0.000398155,0.0001504844,0.000305939,0.001173121],"category_scores_gemma":[0.0006508841,0.0002390032,0.0004159783,0.000230394,0.0003030231,0.0002174901,0.000128554,0.0002425296,0.0003368211],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004762098,"about_ca_system_score_gemma":0.0004031305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004053849,"about_ca_topic_score_gemma":0.002766058,"domain_scores_codex":[0.9997618,0.00007009083,0.00002841445,0.00003357025,0.00004374692,0.00006241961],"domain_scores_gemma":[0.9997556,0.00008028603,0.00003493583,0.00002830161,0.00006028661,0.00004059319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003371428,0.00005520495,0.005845499,0.0001630904,0.0000398167,0.0009442378,0.0002000109,0.0001199049,0.9850287,0.000115439,0.0001081512,0.004008614],"study_design_scores_gemma":[0.0002106397,0.001688891,0.1638833,0.00005003051,0.0001720679,0.007251549,0.0008354819,0.002192934,0.8192114,0.000219106,0.004251198,0.00003330688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955422,0.00328069,0.0004216558,0.00004110227,0.00001867826,0.00001249294,0.000110287,0.000005194122,0.0005677536],"genre_scores_gemma":[0.9966806,0.001099964,0.0004436785,0.00003077154,0.00001191364,0.000009731898,0.000315616,0.000003266415,0.001404465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004053849,"threshold_uncertainty_score":0.008060515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01295712203721778,"score_gpt":0.2667558649739515,"score_spread":0.2537987429367337,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}