{"id":"W2146004287","doi":"10.1158/1535-7163.mct-10-0643","title":"Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; La Trobe University; McGill University; University of Michigan","keywords":"Radiosensitizer; Apoptosis; Cancer research; Head and neck squamous-cell carcinoma; Gene knockdown; Caspase; Radioresistance; Cell culture; Caspase 3; Activator (genetics); Inhibitor of apoptosis; Caspase-9; Medicine; Cancer cell; Chemistry; Programmed cell death; Caspase 8; Cancer; Head and neck cancer; Biology; Radiation therapy; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018353,0.0002485403,0.0001604938,0.0001594155,0.00008724704,0.0001184368,0.0001017992,0.0001752344,0.000732583],"category_scores_gemma":[0.00005185575,0.00006760043,0.0002296827,0.00008303052,0.00009111239,0.0001060737,0.00008989167,0.0003647475,0.0001547167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000167462,"about_ca_system_score_gemma":0.000176221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003409505,"about_ca_topic_score_gemma":0.0006665032,"domain_scores_codex":[0.9999535,0.000009196443,0.000005714112,0.000008092954,0.00001303142,0.00001052927],"domain_scores_gemma":[0.9999775,0.000003477422,0.000006106407,0.000003308813,0.000004376285,0.000005303654],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000560628,0.00003291578,0.00007188741,0.00002976212,0.000003348261,0.00002397352,0.000004951171,0.00004624522,0.9987398,0.00002906664,0.00001623572,0.0009457225],"study_design_scores_gemma":[0.00001249205,0.0005026869,0.001445453,0.000002687824,0.00001056803,0.0001395135,0.00001109337,0.0003896284,0.9964881,0.00001099298,0.0009849387,0.000001854886],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995451,0.002127358,0.001273868,0.00004733686,0.00002480091,0.00004275253,0.0001354771,0.00003135161,0.0008659901],"genre_scores_gemma":[0.9964353,0.001135464,0.001143284,0.00002570752,0.000006323499,0.00003078651,0.0002655772,0.000003922719,0.0009535724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000732583,"threshold_uncertainty_score":0.002450705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162316544434196,"score_gpt":0.2455346734671609,"score_spread":0.2239115080228189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}