{"id":"W2146004287","doi":"10.1158/1535-7163.mct-10-0643","title":"Radiosensitization of Head and Neck Squamous Cell Carcinoma by a SMAC-Mimetic Compound, SM-164, Requires Activation of Caspases","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; La Trobe University; McGill University; University of Michigan","keywords":"Radiosensitizer; Apoptosis; Cancer research; Head and neck squamous-cell carcinoma; Gene knockdown; Caspase; Radioresistance; Cell culture; Caspase 3; Activator (genetics); Inhibitor of apoptosis; Caspase-9; Medicine; Cancer cell; Chemistry; Programmed cell death; Caspase 8; Cancer; Head and neck cancer; Biology; Radiation therapy; Internal medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005963249,0.0001446336,0.0001688129,0.00004702126,0.00003943083,0.000006372643,0.00007327947,0.0001368995,0.00001000495],"category_scores_gemma":[0.000004362839,0.000142237,0.00006111109,0.00009056488,0.00008946034,0.000005424794,0.00003408435,0.00004307627,1.779898e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001588459,"about_ca_system_score_gemma":0.00004741767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003502632,"about_ca_topic_score_gemma":0.00002183292,"domain_scores_codex":[0.9992143,0.00005932515,0.0002322141,0.0002252381,0.0001311035,0.0001378545],"domain_scores_gemma":[0.9994118,0.000007497203,0.0001902077,0.0002331624,0.0001181197,0.00003923935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001735798,0.00009863549,0.001779421,0.00007833116,0.00003690933,0.000001909865,0.0002488063,0.00009159226,0.9917547,0.0001202815,0.00002296934,0.005592929],"study_design_scores_gemma":[0.0008150472,0.0005318375,0.002934234,0.00001738717,0.00008755012,0.000005982018,0.00006233393,0.0005541159,0.9939486,0.000150109,0.0007420674,0.0001507341],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787656,0.005329132,0.01535148,0.00002987112,0.00006663456,0.0002090555,0.00002563446,0.000005998036,0.0002166098],"genre_scores_gemma":[0.9983181,0.000447815,0.0008389936,0.0001566243,0.00002618928,0.000009278118,0.0001033729,0.00002893717,0.00007063379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01955257,"threshold_uncertainty_score":0.5800257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162316544434196,"score_gpt":0.2455346734671609,"score_spread":0.2239115080228189,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}