{"id":"W2146005511","doi":"10.1124/jpet.110.166314","title":"pH Dependence of Organic Anion-Transporting Polypeptide 2B1 in Caco-2 Cells: Potential Role in Antiretroviral Drug Oral Bioavailability and Drug–Drug Interactions","year":2010,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Organic anion-transporting polypeptide; Caco-2; Multidrug resistance-associated protein 2; Atazanavir; Ritonavir; Intestinal epithelium; Efflux; Bioavailability; Organic anion transporter 1; Biochemistry; Organic cation transport proteins; Estrone sulfate; Transporter; Molecular biology; ATP-binding cassette transporter; Pharmacology; Biology; In vitro; Epithelium; Estrone; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000295268,0.0002080893,0.0002842595,0.0001878137,0.0001576215,0.0004221035,0.0002415877,0.0003804762,0.002673893],"category_scores_gemma":[0.0004879443,0.0002142856,0.0002453896,0.0002370795,0.0002798954,0.0005870834,0.0001759637,0.0005843151,0.0005362958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004163623,"about_ca_system_score_gemma":0.0001669846,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001718982,"about_ca_topic_score_gemma":0.001088273,"domain_scores_codex":[0.9997615,0.00006484312,0.00001951826,0.00003382147,0.00006940668,0.00005094102],"domain_scores_gemma":[0.999588,0.0001821933,0.0000751647,0.0000462278,0.00007437974,0.00003403359],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001119238,0.00003534473,0.0005215865,0.0000925417,0.00001036746,0.0001153078,0.00006395644,0.0001257941,0.9962708,0.0001569255,0.0001017687,0.001386478],"study_design_scores_gemma":[0.00004123831,0.0004344198,0.03060503,0.00001367767,0.00002339251,0.0005927869,0.0001338308,0.00311162,0.9619153,0.0001125837,0.002996351,0.00001972317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901523,0.002977746,0.00201808,0.0005591247,0.00004772872,0.00002586434,0.001202031,0.00008353102,0.002933644],"genre_scores_gemma":[0.9951766,0.0007654654,0.001091394,0.00009949999,0.00002120628,0.00001983051,0.0009812838,0.00003090578,0.001813764],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002673893,"threshold_uncertainty_score":0.008945048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009772433182327546,"score_gpt":0.3040672486579767,"score_spread":0.2942948154756492,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}