{"id":"W2146030548","doi":"10.1158/1055-9965.epi-08-0512","title":"Molecular Characterization of MSI-H Colorectal Cancer by <i>MLHI</i> Promoter Methylation, Immunohistochemistry, and Mismatch Repair Germline Mutation Screening","year":2008,"lang":"en","type":"article","venue":"Cancer Epidemiology Biomarkers & Prevention","topic":"Genetic factors in colorectal cancer","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Cancer Care Ontario; inVentiv Health Clinical","funders":"National Cancer Institute; National Institutes of Health; University of Southern California; Mayo Clinic","keywords":"MLH1; Microsatellite instability; Lynch syndrome; Germline mutation; Methylation; Germline; Population; Biology; DNA mismatch repair; Cancer research; Genetics; DNA methylation; Colorectal cancer; Mutation; Cancer; Medicine; Gene; Microsatellite; Gene expression; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004189566,0.0001699847,0.0001740957,0.001206257,0.0001304452,0.0002466292,0.0001889889,0.0002381804,0.0005594853],"category_scores_gemma":[0.001128607,0.0001600372,0.00011193,0.0004231815,0.0001989282,0.0001496365,0.0001653317,0.0001735097,0.0001420854],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135147,"about_ca_system_score_gemma":0.00008362409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001549029,"about_ca_topic_score_gemma":0.001487679,"domain_scores_codex":[0.9997678,0.00004974344,0.00002613273,0.00006316927,0.00006186134,0.00003134074],"domain_scores_gemma":[0.9993,0.0001783389,0.0002850234,0.00004698871,0.00009276724,0.00009672954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002787205,0.00002850934,0.9477332,0.00002416775,0.00004313507,0.0002712967,0.0001470394,0.0001012799,0.04800952,0.00003894529,0.00004968928,0.003274656],"study_design_scores_gemma":[0.00000512021,0.0001504769,0.9923711,0.00000218909,0.00001841667,0.001235435,0.00008686979,0.0003603282,0.005523866,0.00002280571,0.0002204167,0.000003052776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992172,0.0001871414,0.0002178124,0.00001301902,0.000001068885,0.000007533165,0.0001128079,0.000006034987,0.0002374042],"genre_scores_gemma":[0.9994379,0.00007980235,0.0002888735,0.00001058629,0.000004624139,0.000005820277,0.00009344773,0.000001850339,0.00007703459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549029,"threshold_uncertainty_score":0.003079951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0292137607836736,"score_gpt":0.3432903410707662,"score_spread":0.3140765802870926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}