{"id":"W2146032889","doi":"10.1093/intimm/dxh245","title":"Novel simian immunodeficiency virus CTL epitopes restricted by MHC class I molecule Mamu-B*01 are highly conserved for long term in DNA/MVA-vaccinated, SHIV-challenged rhesus macaques","year":2005,"lang":"en","type":"article","venue":"International Immunology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Mount Sinai Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Epitope; Virology; CTL*; Simian immunodeficiency virus; Biology; MHC class I; Modified vaccinia Ankara; Virus; Vaccinia; Immunology; Immune system; Major histocompatibility complex; Antibody; CD8; Genetics; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002161856,0.0004217969,0.0005378334,0.0005301756,0.0002371095,0.00006282811,0.0009453347,0.0005725952,0.0007051937],"category_scores_gemma":[0.0003234856,0.0004031713,0.0001920801,0.0002145296,0.0003990249,0.0002703997,0.0002669963,0.0006547172,0.0007876087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005348296,"about_ca_system_score_gemma":0.0001609665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001155769,"about_ca_topic_score_gemma":0.001962403,"domain_scores_codex":[0.9971787,0.0002703605,0.0007713032,0.0007211909,0.00012259,0.0009358226],"domain_scores_gemma":[0.9984059,0.0004846876,0.0003028225,0.0004609326,0.0002971882,0.00004844177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00218942,0.002046234,0.005923849,0.00001830807,0.001179544,0.00009890611,0.0003339764,0.00002316993,0.9730096,0.001562515,0.004022704,0.009591789],"study_design_scores_gemma":[0.02605161,0.001559704,0.2975843,0.0002153183,0.0001000789,0.0005098474,0.0006564191,0.000181908,0.5717684,0.0002575655,0.09999305,0.001121813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735585,0.01344305,0.000498858,0.00750345,0.0009011985,0.0008804108,0.001377585,0.0001568904,0.001680005],"genre_scores_gemma":[0.9916344,0.001685629,0.0001804591,0.0002939324,0.00005133099,0.0004156618,0.002431221,0.0000489475,0.003258413],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4012412,"threshold_uncertainty_score":0.9999904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02149969177962037,"score_gpt":0.2869618998746483,"score_spread":0.265462208095028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}