{"id":"W2146042468","doi":"10.1152/ajpheart.00198.2002","title":"H<sub>2</sub>O<sub>2</sub>-induced Ca<sup>2+</sup>overload in NRVM involves ERK1/2 MAP kinases: role for an NHE-1-dependent pathway","year":2002,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":95,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Heart, Lung, and Blood Institute","keywords":"Extracellular; Intracellular; Kinase; Chemistry; Phosphorylation; MAPK/ERK pathway; Intracellular pH; Reactive oxygen species; Signal transduction; Biophysics; Biochemistry; Internal medicine; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001405096,0.000357936,0.0005795067,0.0001047965,0.0001424295,0.0002713926,0.0002267018,0.0003449648,0.001858903],"category_scores_gemma":[0.00006763584,0.0001569149,0.0003088635,0.0000907624,0.0003068276,0.0004351968,0.000173074,0.0005920751,0.0003495769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002050683,"about_ca_system_score_gemma":0.0001674155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004331011,"about_ca_topic_score_gemma":0.0008607305,"domain_scores_codex":[0.9999181,0.000007385737,0.000009205014,0.00001772473,0.00001900772,0.00002862044],"domain_scores_gemma":[0.9999366,0.000007545954,0.00001923248,0.000008104712,0.000008136332,0.00002043241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002574153,0.00003377021,0.0001546038,0.00006463232,0.000004393451,0.0000818984,0.00001575395,0.00001614666,0.9987765,0.0000309518,0.00004714845,0.0005167649],"study_design_scores_gemma":[0.00006562787,0.0007008685,0.03299312,0.00002077283,0.00003425854,0.0004864542,0.0001524585,0.001116608,0.9618132,0.0001359556,0.002470945,0.000009765248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927608,0.002511119,0.002276995,0.0002370388,0.00009652679,0.00004528977,0.0005872826,0.00008877857,0.001396121],"genre_scores_gemma":[0.9901868,0.001453573,0.003009042,0.0002485706,0.00007453649,0.0001512168,0.0007364459,0.00005169352,0.004088199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001858903,"threshold_uncertainty_score":0.006218612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01324952679806103,"score_gpt":0.2370305566162497,"score_spread":0.2237810298181887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}