{"id":"W2146047637","doi":"10.1073/pnas.1402926111","title":"Structural basis for the recruitment of glycogen synthase by glycogenin","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Glycogen Storage Diseases and Myoclonus","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Institute for Research in Immunology and Cancer; Université de Montréal; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; British Heart Foundation; Wellcome Trust","keywords":"Allosteric regulation; Glycogen synthase; Glycogen; Glycogen branching enzyme; Glycogenesis; Glycogen debranching enzyme; Biochemistry; Glycogen phosphorylase; Biology; GSK-3; Enzyme; Phosphorylation; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008591163,0.0002248289,0.0001694235,0.00007160218,0.0002743338,0.0002924396,0.0003879916,0.0003043785,0.001871918],"category_scores_gemma":[0.0001538946,0.0001508031,0.0001875714,0.00004749757,0.0002653611,0.0001691933,0.0002510805,0.000468583,0.0007564966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005682007,"about_ca_system_score_gemma":0.0002928614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007197966,"about_ca_topic_score_gemma":0.0006984802,"domain_scores_codex":[0.999953,0.000006318094,0.000002962514,0.00001249541,0.00001285334,0.00001226147],"domain_scores_gemma":[0.9999374,0.000007801847,0.00001143016,0.000004242842,0.000007947595,0.00003114777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001946894,0.00007265549,0.0007616398,0.00007324811,0.0000102648,0.0004315104,0.00004213238,0.001188695,0.992038,0.002769866,0.0003518609,0.002065378],"study_design_scores_gemma":[0.0002095786,0.0006149649,0.02594736,0.00005784374,0.00002938344,0.001269177,0.0001620712,0.03646043,0.9174919,0.00327023,0.01443395,0.00005318863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895069,0.0006271016,0.004546154,0.000261428,0.00008384966,0.00003384645,0.00010112,0.0001393553,0.00470015],"genre_scores_gemma":[0.9963451,0.000199811,0.001612741,0.000109571,0.00001141729,0.00001523797,0.0002117808,0.00001561722,0.001478782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001871918,"threshold_uncertainty_score":0.006262183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07375421085094414,"score_gpt":0.342988254251556,"score_spread":0.2692340434006119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}