{"id":"W2146074741","doi":"10.2337/diabetes.50.3.534","title":"The Prohormone Convertase Enzyme 2 (PC2) Is Essential for Processing Pro-Islet Amyloid Polypeptide at the NH2-Terminal Cleavage Site","year":2001,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; Canadian Institutes of Health Research; National Institutes of Health; Medical Research Council Canada; University of Washington; Howard Hughes Medical Institute","keywords":"Prohormone convertase; Islet; Proinsulin; Amylin; Prohormone; Amyloid precursor protein; Protein precursor; Biology; Biochemistry; Amyloid (mycology); Enzyme; Chemistry; Molecular biology; Endocrinology; Internal medicine; Insulin; Hormone; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001310769,0.001268485,0.0003588228,0.000490404,0.0001903986,0.0006350272,0.0002455024,0.0003879141,0.001048337],"category_scores_gemma":[0.0001660348,0.0002392348,0.0003707478,0.0003606672,0.0003102341,0.0003593015,0.0002648114,0.0005143662,0.0005208558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973189,"about_ca_system_score_gemma":0.0002460721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006977628,"about_ca_topic_score_gemma":0.0005572384,"domain_scores_codex":[0.9998066,0.0000175548,0.0000198272,0.0000614676,0.00005813605,0.0000364549],"domain_scores_gemma":[0.9997327,0.0000427979,0.00009429741,0.00002780035,0.00002074591,0.00008176934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002193647,0.0000265476,0.0007772798,0.00004635118,0.00001162509,0.0001661494,0.000008557523,0.00003442707,0.9973879,0.00007121228,0.00003114608,0.00121945],"study_design_scores_gemma":[0.00004060491,0.0001920915,0.02056472,0.00001005288,0.00004692456,0.001731467,0.00002435427,0.0005847862,0.9729759,0.00007411248,0.003744643,0.00001030184],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904224,0.00315663,0.004312963,0.00008741162,0.00004365072,0.00003191972,0.0008860904,0.0001399104,0.0009189223],"genre_scores_gemma":[0.9871588,0.002390225,0.004583612,0.00005970587,0.00003124945,0.0000508582,0.002787104,0.00006773141,0.002870591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001268485,"threshold_uncertainty_score":0.003507018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01313550279239309,"score_gpt":0.2608969984051934,"score_spread":0.2477614956128003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}