{"id":"W2146118298","doi":"10.1373/clinchem.2011.173286","title":"Two-Step Biochemical Differential Diagnosis of Classic 21-Hydroxylase Deficiency and Cytochrome P450 Oxidoreductase Deficiency in Japanese Infants by GC-MS Measurement of Urinary Pregnanetriolone/ Tetrahydroxycortisone Ratio and 11β-Hydroxyandrosterone","year":2012,"lang":"en","type":"article","venue":"Clinical Chemistry","topic":"Sexual Differentiation and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Ministry of Health, British Columbia; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Internal medicine; Endocrinology; Androstenedione; Urine; Differential diagnosis; Metabolite; 21-Hydroxylase; Urinary system; Creatinine; Chemistry; Medicine; Congenital adrenal hyperplasia; Pathology; Androgen; Hormone","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005482511,0.0005344786,0.0004645754,0.001282504,0.0003455726,0.0004126984,0.0002951242,0.0003924656,0.0004769521],"category_scores_gemma":[0.001330452,0.000264847,0.0003025779,0.0006094336,0.000383559,0.0001865702,0.0004293918,0.0003058098,0.0001010314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003556483,"about_ca_system_score_gemma":0.0003499467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005323833,"about_ca_topic_score_gemma":0.00423075,"domain_scores_codex":[0.9995285,0.00008125681,0.0001040491,0.0001036797,0.000112745,0.00006976169],"domain_scores_gemma":[0.9996119,0.00008642911,0.0001005557,0.00001988763,0.00009840832,0.00008277033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001867793,0.00002720664,0.9842122,0.00002828611,0.00002245024,0.002689062,0.0002413649,0.00004584634,0.009517194,0.00002421016,0.00004135884,0.002963964],"study_design_scores_gemma":[0.00001447191,0.0002443041,0.9834681,0.00002156395,0.00006318896,0.009875746,0.000504968,0.0007362017,0.004697639,0.00003276408,0.0003330238,0.000008068124],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991059,0.0003171006,0.0002649209,0.00001558601,0.000003525482,0.00001553691,0.0000423949,0.000006034884,0.0002290022],"genre_scores_gemma":[0.9988503,0.000155947,0.0007751102,0.00003193314,0.000004653799,0.00001530332,0.00007984356,0.000002139891,0.00008474173],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005323833,"threshold_uncertainty_score":0.01058567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0225175490605667,"score_gpt":0.2923706053229116,"score_spread":0.2698530562623449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}